Rchr
J-GLOBAL ID:202201020023467153
Update date: Oct. 15, 2024
Nagae Genta
Nagae Genta | Nagae Genta
Affiliation and department:
Job title:
Project Associate Professor
Homepage URL (2):
https://www.rcast.u-tokyo.ac.jp/ja/research/people/staff-nagae_genta.html
,
https://www.rcast.u-tokyo.ac.jp/en/research/people/staff-nagae_genta.html
Research field (4):
Genomics
, Gastroenterology
, Systems genomics
, Tumor biology
Research theme for competitive and other funds (21):
- 2024 - 2029 A Study on Elucidating Obesity and Lifestyle Diseases through the Epigenome-RNA Modification Axis
- 2023 - 2026 Exploring Abnormal RNA Modifications in Glioma using direct RNA Nanopore Sequencing
- 2023 - 2026 脳腫瘍の免疫血管微小環境と放射線画像radiomics解析の融合を基にした新規治療開発
- 2024 - 2026 Elucidation of therapeutic resistance caused by complex molecular aberrations and tumor microenvironment
- 2021 - 2025 Elucidation of mRNA dysregulation in hepatocellular carcinoma using a novel mRNA methylome method
- 2020 - 2023 マルチオミクス統合解析を基にしたグリオーマ再発・悪性化機構解明と新規治療戦略創出
- 2022 - 2023 薬剤耐性パーシスター細胞の代謝的適応に対する創薬ポイントの開発
- 2022 - 2023 新規バイオマーカーを用いた小児肝腫瘍のリキッドバイオプシー創出研究
- 2021 - 2022 がんゲノム医療の推進に資する小児がんの包括的ゲノムデータ基盤の構築と展開
- 2018 - 2021 Cellular deconvolution analysis of hepatocellular carcinoma based on the systemic epigenomic profiles
- 2017 - 2020 The elucidation of the mechanism of the development and progression of gliomas due to epigenetic deregulation and the identification of therapeutic targets
- 2015 - 2020 4D Chromosome structural information during differentiation
- 2016 - 2020 大腸がんに対する抗EGFR抗体薬の効果を予測する新規バイオマーカー・DNAメチル化状態診断キットの開発
- 2015 - 2019 Epigenomic analysis of stem cell characteristics defining therapeutic resistance of liver cancer
- 2017 - 2019 スキルス胃がんにおける変異型RHOAに対する創薬ポイントの確立
- 2016 - 2018 神経膠腫(グリオーマ)の治療抵抗性に関連した不均一性獲得機構の解明とそれに対応する治療戦略の構築
- 2015 - 2017 メチル化DNAオートコレクターの開発
- 2013 - 2016 Aberrant hydroxymethylation in human liver cancer
- 2014 - 2015 がん診断のための血中メチル化DNAの簡易検出法の開発
- 2011 - 2015 悪性脳腫瘍克服のための新規治療標的及びバイオマーカーの創出
- 2011 - 2012 Epigenetic dysregulation during development of HCC
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Papers (70):
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Takeshi Marumo, Naoto Yoshida, Noriko Inoue, Masayuki Yamanouchi, Yoshifumi Ubara, Shinji Urakami, Takeshi Fujii, Yutaka Takazawa, Kenichi Ohashi, Wakako Kawarazaki, et al. Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes. American journal of physiology. Renal physiology. 2024. 327. 3. F397-F411
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Akira Nishijima, Katsutoshi Oda, Kosei Hasegawa, Takahiro Koso, Kayo Asada, Yuji Ikeda, Ayumi Taguchi, Daichi Maeda, Genta Nagae, Shingo Tsuji, et al. Integrated genomic/epigenomic analysis stratifies subtypes of clear cell ovarian carcinoma, highlighting their cellular origin. Scientific reports. 2024. 14. 1. 18797-18797
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Sina Neyazi, Erika Yamazawa, Karoline Hack, Shota Tanaka, Genta Nagae, Catena Kresbach, Takayoshi Umeda, Alicia Eckhardt, Kenji Tatsuno, Lara Pohl, et al. Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation. Acta Neuropathologica. 2024. 147. 1
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Amélie Roehrig, Theo Hirsch, Aurore Pire, Guillaume Morcrette, Barkha Gupta, Charles Marcaillou, Sandrine Imbeaud, Christophe Chardot, Emmanuel Gonzales, Emmanuel Jacquemin, et al. Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma. Nature Communications. 2024. 15. 1. 3031-3031
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Aurore Pire, Theo Z. Hirsch, Guillaume Morcrette, Sandrine Imbeaud, Barkha Gupta, Jill Pilet, Marianna Cornet, Monique Fabre, Catherine Guettier, Sophie Branchereau, et al. Mutational signature, cancer driver genes mutations and transcriptomic subgroups predict hepatoblastoma survival. European Journal of Cancer. 2024
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MISC (21):
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柴田龍弘. がんゲノムペディア -77のキーワードで理解するゲノム医療とゲノム研究. 2024. 104-107
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永江玄太. 総論:疾患の病態解明に向けた統合オミックス解析. 遺伝子医学 統合オミックス解析. 2023. 13. 3
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永江 玄太. 小児肝芽腫発症に関与する分化制御因子. 生化学. 2022. 94. 3. 438-442
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永江 玄太. 【がんゲノム医療時代の分子腫瘍学】(第1部)がんの分子病理学(序論) 解析法 ヒトゲノム研究におけるマイクロアレイ解析(CGH・SNP・メチル化など). 病理と臨床. 2022. 40. 臨増. 057-063
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永江 玄太. 泌尿器科領域におけるシングルセル解析の可能性. 泌尿器科. 2022. 15. 4. 465-471
more...
Patents (3):
Education (2):
- - 2008 The University of Tokyo Graduate School of Medicine
- - 2000 The University of Tokyo Faculty of Medicine School of Medicine
Professional career (2):
- M.D. (The University of Tokyo)
- Ph.D. (The University of Tokyo)
Work history (10):
- 2021/04 - 現在 The University of Tokyo Research Center for Advanced Science and Technology Project Associate Professor
- 2017/07 - 2021/03 The University of Tokyo Research Center for Advanced Science and Technology Lecturer
- 2018/04 - 2019/03 University of Cambridge Clare Hall College Visiting Fellow
- 2018/04 - 2019/03 Wellcome Sanger Institute Visiting Scientist
- 2015/10 - 2017/06 The University of Tokyo Research Center for Advanced Science and Technology Project Lecturer
- 2010/10 - 2015/09 The University of Tokyo Research Center for Advanced Science and Technology
- 2008/04 - 2010/09 The University of Tokyo Research Center for Advanced Science and Technology Project Researcher
- 2002/06 - 2004/03 Jichi Medical University Hospital Senior Resident
- 2001/06 - 2002/05 NTT Medical Center Tokyo Junior Resident
- 2000/05 - 2001/05 The University of Tokyo Faculty of Medicine University Hospital Junior Resident
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Committee career (1):
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