Art

J-GLOBAL ID：202202221723134722   Reference number：22A1025829

ZDQ-0620, a Novel Phosphatidylinositol 3-Kinase Inhibitor, Inhibits Colorectal Carcinoma Cell Proliferation and Suppresses Angiogenesis by Attenuating PI3K/AKT/mTOR Pathway

新規ホスファチジルイノシトール3-キナーゼ阻害剤ZDQ-0620は大腸癌細胞増殖を抑制し,PI3K/AKT/mTOR経路を減衰させることにより血管新生を抑制する【JST・京大機械翻訳】

Author (10)： Qin Xiaochun (1Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, China) ,  Qin Xiaochun (2Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, China) ,  Liu Mingyue (2Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, China) ,  Xu Chang (2Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, China) ,  Xing Bo (2Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, China) ,  Xu Xiangbo (2Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, China) ,  Wu Yuting (2Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, China) ,  Ding Huaiwei (3Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China) ,  Zhao Qingchun (1Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, China) ,  Zhao Qingchun (2Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, China)
Material： Frontiers in Oncology (Web)
Volume： 12  Page： 848952  Publication year： 2022 
JST Material Number： U7089A  ISSN： 2234-943X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The PI3K/AKT pathway plays a c...

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Thesaurus term： target ,  antitumor action ,  aorta ,  human(primates) ,  rat ,  therapy ,  flow cytometry ,  targeting ,  colonic neoplasm ,  rectal neoplasm ,  *angiogenesis ,  apoptosis ,  VEGF
Semi thesaurus term： 悪性腫瘍 ,  腫瘍進行 ,  結腸直腸癌 ,  *キナーゼ , 【Automatic Indexing@JST】

Author keywords (5)： colorectal cancer ,  cell cycle arrest ,  apoptosis ,  angiogenesis ,  PI3K

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cell physiology in general  (EF02010S)

Reference (51)：

• Montminy EM, Karlitz JJ, Landreneau SW. Progress of Colorectal Cancer Screening in United States: Past Achievements and Future Challenges. Prev Med (2019) 120:78-84. doi: doi: 10.1016/j.ypmed.2018.12.004
• Zavoral M, Suchanek S, Majek O, Fric P, Minarikova P, Minarik M, et al. Colorectal Cancer Screening: 20 Years of Development and Recent Progress. World J Gastroenterol (2014) 20(14):3825-34. doi: doi: 10.3748/wjg.v20.i14.3825
• Pochapin MB. 2017 Emily Couric Memorial Lecture: Colorectal Cancer: Polyps, Prevention, and Progress. Am J Gastroenterol (2018) 113(12):1772-7. doi: doi: 10.1038/s41395-018-0187-4
• Ortega J, Vigil CE, Chodkiewicz C. Current Progress in Targeted Therapy for Colorectal Cancer. Cancer Control (2010) 17(1):7-15. doi: doi: 10.1177/107327481001700102
• Biller LH, Schrag D. Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review. JAMA (2021) 325(7):669-85. doi: doi: 10.1001/jama.2021.0106

Terms in the title (9)： ホスファチジルイノシトール3-キナーゼ阻害剤 ,  大腸癌細胞 ,  増殖 ,  PI3K ,  Akt ,  mTOR ,  経路 ,  減衰 ,  血管新生