Art

J-GLOBAL ID：202202224821839676   Reference number：22A1663249

Discovery of 4-methoxy-N-(1-naphthyl)benzenesulfonamide derivatives as small molecule dual-target inhibitors of tubulin and signal transducer and activator of transcription 3 (STAT3) based on ABT-751

ABT-751に基づくチューブリンおよびシグナルトランスデューサの小分子二重標的阻害剤としての4-メトキシ-N-(1-ナフチル)ベンゼンスルホンアミド誘導体の発見および転写3(STAT3)の活性化因子【JST・京大機械翻訳】

Author (19)： Wang Xuebao (Department of Colorectal Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China) ,  Wang Xuebao (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Wang Xuebao (Platform for Radiation Protection and Emergency Preparedness of Southern Zhejiang, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Lu Ying (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Sun Doudou (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Qian Jinheng (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Tu Sijun (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Yue Weixia (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Lin Humin (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Tang Haijie (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Meng Fanxi (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  He Qin (Dong Medicine Key Laboratory of Hunan Province, Hunan University of Medicine, Huaihua, Hunan 418000, China) ,  Xie Zixin (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Zhang Yuan (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Chen Huijun (Department of Pharmacy, the First People’s Hospital of Taizhou, Taizhou, Zhejiang 318020, China) ,  Ma Shumei (Platform for Radiation Protection and Emergency Preparedness of Southern Zhejiang, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China) ,  Zuo Zhigui (Department of Colorectal Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China) ,  Ye Faqing (Department of Colorectal Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China) ,  Ye Faqing (School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China)
Material： Bioorganic Chemistry  (Bioorg Chem)
Volume： 125  Page： Null  Publication year： 2022 
JST Material Number： E0823A  ISSN： 0045-2068  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Overexpressed tubulin and cont...

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Thesaurus term： optimization ,  polymerization ,  antitumor action ,  antitumor drug ,  tumor ,  phosphorylation ,  binding site ,  heterotrans plantation ,  *tubulin ,  *small molecule ,  gene expression ,  targeting ,  in vitro experiment ,  alicyclic compound ,  fatty acid ,  enol ether ,  carboxamide ,  phenol ether ,  enone ,  polynuclear aromatic compound ,  side chain amine alkaloid
Semi thesaurus term： *STAT3転写因子 ,  過剰発現 , 【Automatic Indexing@JST】

Author keywords (5)： Tubulin ,  STAT3 ,  Dual-target inhibitor ,  Anti-tumor ,  DL14

JST classification (1)： Enzyme in general  (EB09010D)

Substance index (1)： Colchicine

Terms in the title (11)： チューブリン ,  シグナル ,  トランスデューサ ,  小分子 ,  標的 ,  阻害剤 ,  ベンゼン ,  スルホンアミド誘導体 ,  発見 ,  転写 ,  STAT3