Art

J-GLOBAL ID：202202224903311302   Reference number：22A1438432

Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation

抗原由来ペプチドはERストレスセンサーIRE1αをCurb樹状細胞交差提示にゲージする【JST・京大機械翻訳】

Author (14)： Guttman Ofer (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Le Thomas Adrien (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Marsters Scot (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Lawrence David A. (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Gutgesell Lauren (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Zuazo-Gaztelu Iratxe (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Harnoss Jonathan M. (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Haag Simone M. (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Murthy Aditya (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Strasser Geraldine (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Modrusan Zora (Departments of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA) ,  Wu Thomas (Departments of Oncology Bioinformatics, Genentech, South San Francisco, CA) ,  Mellman Ira (Departments of Cancer Immunology, Genentech, South San Francisco, CA) ,  Ashkenazi Avi (Departments of Cancer Immunology, Genentech, South San Francisco, CA)
Material： Journal of Cell Biology  (JCB)
Volume： 221  Issue： 6  Page： Null  Publication year： 2022 
JST Material Number： C0575A  ISSN： 0021-9525  CODEN： JCLBA3  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Dendritic cells (DCs) promote ...

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Thesaurus term： hydrophobic ,  *peptide ,  mRNA ,  *antigen ,  antibody ,  endoplasmic reticulum ,  translation(genetics) ,  *dendritic cell ,  epitope ,  tumor invasion ,  protein complex ,  *ER stress
Semi thesaurus term： CD8陽性T細胞 ,  *クロスプレゼンテーション ,  担癌マウス , 【Automatic Indexing@JST】

JST classification (1)： Cell physiology in general  (EF02010S)

Reference (90)：

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• Alloatti. Dendritic cell maturation and cross-presentation: Timing matters!. Immunol. Rev. 2016, 272, 97. doi:10.1111/imr.12432
• Amin-Wetzel. A J-protein co-chaperone recruits BiP to monomerize IRE1 and repress the unfolded protein response. Cell. 2017, 171, 1625. doi:10.1016/j.cell.2017.10.040
• Bae. Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress. J. Cell Biol. 2019, 218, 1118. doi:10.1083/jcb.201809027
• Barber. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006, 439, 682. doi:10.1038/nature04444

Terms in the title (8)： 抗原 ,  ペプチド ,  ERストレス ,  センサー ,  IRE1α ,  樹状細胞 ,  交差提示 ,  ゲージ