Art

J-GLOBAL ID：202202232032179374   Reference number：22A2236311

CDKN2A-mediated molecular subtypes characterize the hallmarks of tumor microenvironment and guide precision medicine in triple-negative breast cancer

CDKN2A仲介分子サブタイプは,トリプルネガティブ乳癌における腫瘍微小環境およびガイド精密医療の特徴を特徴付ける【JST・京大機械翻訳】

Author (10)： Cheng Tianyi (1Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao, Macao SAR, China) ,  Wu Yingyi (1Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao, Macao SAR, China) ,  Wu Yingyi (2Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery, Macau University of Science and Technology, Macao, Macao SAR, China) ,  Liu Zhiyu (1Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao, Macao SAR, China) ,  Yu Yi (1Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao, Macao SAR, China) ,  Sun Shixue (3Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China) ,  Guo Min (4Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, China) ,  Sun Baoqing (5Department of Allergy and Clinical Immunology, Department of Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospi...) ,  Huang Chen (1Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao, Macao SAR, China) ,  Huang Chen (2Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery, Macau University of Science and Technology, Macao, Macao SAR, China)
Material： Frontiers in Immunology (Web)
Volume： 13  Page： 970950  Publication year： 2022 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Currently, breast cancer (BRCA...

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Thesaurus term： gene ,  immunotherapy ,  dominance ,  prognosis ,  population(statistics) ,  *breast tumor ,  EGF receptor ,  biomarker ,  *p16 gene ,  *Individualized Medicine ,  Ferroptosis
Semi thesaurus term： 癌治療 ,  予後因子 ,  *トリプルネガティブ乳癌 ,  *腫瘍内微小環境 , 【Automatic Indexing@JST】

Author keywords (5)： cuproptosis ,  immunotherapy ,  tumor microenvironment ,  triple-negative breast cancer ,  cyclin-dependent kinase inhibitor 2A

JST classification (1)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (77)：

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• Dawson SJ, Provenzano E, Caldas C. Triple negative breast cancers: clinical and prognostic implications. Eur J Cancer. (2009) 45 Suppl 1:27-40. doi: doi: 10.1016/S0959-8049(09)70013-9
• Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res (2007) 13(15 Pt 1):4429-34. doi: doi: 10.1158/1078-0432.CCR-06-3045
• Chan SH, Chiang J, Ngeow J. CDKN2A germline alterations and the relevance of genotype-phenotype associations in cancer predisposition. Hereditary Cancer Clin practice. (2021) 19(1):21. doi: doi: 10.1186/s13053-021-00178-x
• Liggett WH Jr., Sidransky D. Role of the p16 tumor suppressor gene in cancer. J Clin Oncol (1998) 16(3):1197-206. doi: doi: 10.1200/JCO.1998.16.3.1197

Terms in the title (7)： CDKN2A ,  仲介 ,  分子 ,  サブタイプ ,  トリプルネガティブ乳癌 ,  腫瘍微小環境 ,  精密医療