Art

J-GLOBAL ID：202202233673710030   Reference number：22A1176611

The Emerging Role of N6-Methyladenosine RNA Methylation as Regulators in Cancer Therapy and Drug Resistance

癌治療と薬物耐性における調節因子としてのN6-メチルアデノシンRNAメチル化の新たな役割【JST・京大機械翻訳】

Author (8)： Chen Zhaolin (1Division of Life Sciences and Medicine, Department of Pharmacy, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, China) ,  Hu Ying (2Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, China) ,  Jin Le (1Division of Life Sciences and Medicine, Department of Pharmacy, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, China) ,  Yang Fan (3Department of Clinical Medical, The First Clinical Medical College, Anhui Medical University, Hefei, China) ,  Ding Haiwen (1Division of Life Sciences and Medicine, Department of Pharmacy, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, China) ,  Zhang Lei (1Division of Life Sciences and Medicine, Department of Pharmacy, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, China) ,  Li Lili (4Department of Hematopathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China) ,  Pan Tingting (5Division of Life Sciences and Medicine, Department of General Surgery, Diagnosis and Therapy Center of Thyroid and Breast, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, China)
Material： Frontiers in Pharmacology (Web)
Volume： 13  Page： 873030  Publication year： 2022 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： N6-methyladenosine (m<sup>6</s...

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Thesaurus term： interaction ,  *methylation ,  *RNA ,  mRNA ,  antiserum ,  human(primates) ,  *drug resistance ,  methyltransferase ,  eucaryote ,  RNA methyltransferase ,  tumorigenesis
Semi thesaurus term： 分子機構 ,  *調節因子 ,  *癌治療 ,  *RNAメチル化 , 【Automatic Indexing@JST】

Author keywords (5)： N6-methyladenosine (m6A) ,  RNA methylation ,  inflammation ,  cancer ,  therapeutic targets

JST classification (1)： Gene expression  (EC02040Q)

Reference (189)：

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• BarbieriI., TzelepisK., PandolfiniL., ShiJ., Millán-ZambranoG., RobsonS. C., et al (2017). Promoter-bound METTL3 Maintains Myeloid Leukaemia by m6A-dependent Translation Control. Nature 552, 126-131. doi: 10.1038/nature24678
• BiX., LvX., LiuD., GuoH., YaoG., WangL., et al (2021). METTL3-mediated Maturation of miR-126-5p Promotes Ovarian Cancer Progression via PTEN-Mediated PI3K/Akt/mTOR Pathway. Cancer Gene Ther. 28, 335-349. doi: 10.1038/s41417-020-00222-3
• BianS., NiW., ZhuM., SongQ., ZhangJ., NiR., et al (2020). Identification and Validation of the N6-Methyladenosine RNA Methylation Regulator YTHDF1 as a Novel Prognostic Marker and Potential Target for Hepatocellular Carcinoma. Front. Mol. Biosci. 7, 604766. doi: 10.3389/fmolb.2020.604766

Terms in the title (5)： 癌治療 ,  薬物耐性 ,  調節因子 ,  RNAメチル化 ,  役割