Art

J-GLOBAL ID：202202235619189857   Reference number：22A1023631

The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis

SARS-CoV-2と不良転帰に対してより脆弱な癌患者の潜在的メカニズム:汎癌バイオインフォマティクス解析【JST・京大機械翻訳】

Author (17)： Huang Xinwei (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Liang Huazheng (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Zhang Hong (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Tian Li (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Cong Peilin (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Wu Tingmei (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Zhang Qian (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Gao Xiaofei (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Li Wanrong (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Chen Aiwen (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Zhang Yuxin (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Dong Qianyu (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Wan Hanxi (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  He Mengfan (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Dai Danqing (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Li Zhen (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China) ,  Xiong Lize (Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China)
Material： Frontiers in Immunology (Web)
Volume： 12  Page： 804387  Publication year： 2021 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： To explore the potential mecha...

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Thesaurus term： risk ,  immersional wetting ,  *gene ,  genotype ,  sensitivity ,  mutant ,  immunological reaction ,  lung tumor
Semi thesaurus term： *重症急性呼吸器症候群 ,  *バイオインフォマティクス ,  脆弱性 ,  アンギオテンシン変換酵素2 ,  *癌患者 ,  重症度 ,  有害転帰 , 【Automatic Indexing@JST】

Author keywords (5)： COVID-19 ,  cancer ,  rs10774671 (OAS1) ,  SARS-CoV-2 ,  ACE2

JST classification (4)： Molecular genetics in general  (EC02010J) ,  Tumors(=neoplasms)of digestive system  (GH04000D) ,  Digestive system diseases  (GH03000W) ,  Genetic variation  (EC01030Y)

Reference (33)：

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• Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-Cov-2 Cell Entry Depends On ACE2 And TMPRSS2 And Is Blocked By A Clinically Proven Protease Inhibitor. Cell (2020) 181:271-80.E278. doi: doi: 10.1016/J.Cell.2020.02.052
• Hoagland DA, Clarke DJB, Møller R, Han Y, Yang L, Wojciechowicz ML, et al. Modulating The Transcriptional Landscape Of SARS-Cov-2 As An Effective Method For Developing Antiviral Compounds. Biorxiv (2020) 2020.2007.2012.199687. doi: doi: 10.1101/2020.07.12.199687
• Kong Q, Xiang Z, Wu Y, Gu Y, Guo J, Geng F. Analysis Of The Susceptibility of Lung Cancer Patients To SARS-Cov-2 Infection. Mol Cancer (2020) 19:80. doi: doi: 10.1186/S12943-020-01209-2
• Banday AR, Stanifer ML, Florez-Vargas O, Onabajo OO, Zahoor MA, Papenberg BW, et al. Genetic Regulation Of OAS1 Nonsense-Mediated Decay Underlies Association With Risk Of Severe COVID-19. Medrxiv (2021). doi: doi: 10.1101/2021.07.09.21260221

Terms in the title (6)： SARS-CoV-2 ,  転帰 ,  癌患者 ,  メカニズム ,  癌 ,  バイオインフォマティクス解析