Art

J-GLOBAL ID：202202244639975969   Reference number：22A1242367

Development of an efficient and precise adenine base editor (ABE) with expanded target range in allotetraploid cotton (Gossypium hirsutum)

異質四倍体ワタ(Gossypium hirsutum)における拡大標的範囲を持つ効率的で正確なアデニン塩基エディタ(ABE)の開発【JST・京大機械翻訳】

Author (18)： Guanying Wang, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Zhongping Xu, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Fuqiu Wang, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Yuefan Huang, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Yanfeng Xin, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Sijia Liang, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Bo Li, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Bo Li, (Xinjiang Key Laboratory of Crop Biotechnology, Institute of Nuclear and Biological Technology, Xinjiang Academy of Agricultural Sciences, Wulumuqi, People’s Republic of China) ,  Huan Si, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Lin Sun, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Qiongqiong Wang, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Xiao Ding, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Xiangqian Zhu, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Luo Chen, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Lu Yu, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Keith Lindsey, (Department of Biosciences, Durham University, Durham, UK) ,  Xianlong Zhang, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China) ,  Shuangxia Jin, (National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, People’s Republic of China)
Material： BMC Biology (Web)
Volume： 20  Issue： 1  Page： 1-15  Publication year： 2022 
JST Material Number： U7046A  ISSN： 1741-7007  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Base editors (BEs) display div...

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Thesaurus term： Zea mays ,  DNA ,  RNA ,  Triticum aestivum ,  Glycine max ,  protein ,  Oryza sativa ,  *genome ,  allele ,  aneuploid ,  vector(genetics) ,  Arabidopsis ,  single nucleotide polymorphism ,  nitrogen heterocyclic compound
Semi thesaurus term： Cas9 , 【Automatic Indexing@JST】

Author keywords (6)： Cotton ,  CRISPR/nCas9 ,  dCas9 ,  dCpf1 ,  Adenine base editors (ABEs) ,  Off-target mutations

JST classification (2)： Structure and chemistry of genes  (EC02020U) ,  Textile plants(=fiber plants)  (FC03077U)

Substance index (1)： Adenine

Reference (66)：

• Mol Plant; PhieCBEs: plant high-efficiency cytidine base editors with expanded target range; D Zeng, T Liu, J Tan, Y Zhang, Z Zheng, B Wang, D Zhou, X Xie, M Guo, Y-G Liu, Q Zhu; 13; 12; 2020; 1666-1669; 10.1016/j.molp.2020.11.001; citation_id=CR1
• Nat Plants; Precision genome engineering through adenine and cytosine base editing; J-S Kim; 4; 3; 2018; 148-151; 10.1038/s41477-018-0115-z; citation_id=CR2
• Natl Sci Rev; Gene editing in plants: progress and challenges; Y Mao, JR Botella, Y Liu, J-K Zhu; 6; 3; 2019; 421-437; 10.1093/nsr/nwz005; citation_id=CR3
• Emerg Top Life Sci; Recent advances in DNA-free editing and precise base editing in plants; Y Zhang, C Gao; 1; 2; 2017; 161-168; 10.1042/ETLS20170021; citation_id=CR4
• Adv Sci; CRISPR/Cas systems in genome editing: methodologies and tools for sgRNA design, off-target evaluation, and strategies to mitigate off-target effects; H Manghwar, B Li, X Ding, A Hussain, K Lindsey, X Zhang, S Jin; 7; 6; 2020; 1902312-1902327; 10.1002/advs.201902312; citation_id=CR5

Terms in the title (9)： ワタ ,  Gossypium ,  拡大 ,  標的 ,  アデニン ,  塩基 ,  エディタ ,  ABE ,  開発