Art

J-GLOBAL ID：202202250695036807   Reference number：22A1020738

Natural Products as a Novel Therapeutic Strategy for NLRP3 Inflammasome-Mediated Gout

NLRP3インフラマソーム仲介痛風の新規治療戦略としての天然物【JST・京大機械翻訳】

Author (5)： Lee Jun Ho (1College of Korea Medicine, Woosuk University, Jeonju-si, South Korea) ,  Kim Hyuk Soon (2Department of Biomedical Sciences, College of Natural Science and Department of Health Sciences, The Graduate School of Dong-A University, Busan, South Korea) ,  Lee Jun-Ho (1College of Korea Medicine, Woosuk University, Jeonju-si, South Korea) ,  Yang Gabsik (1College of Korea Medicine, Woosuk University, Jeonju-si, South Korea) ,  Kim Hong Jun (1College of Korea Medicine, Woosuk University, Jeonju-si, South Korea)
Material： Frontiers in Pharmacology (Web)
Volume： 13  Page： 861399  Publication year： 2022 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Gout is the most common form o...

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Thesaurus term： target ,  crystal ,  inflammation ,  serum ,  *gout ,  side effect ,  reaction mechanism ,  targeting ,  hyperuricemia ,  *therapeutic planning ,  cytokine ,  *protein complex ,  interleukin 1 ,  inflammatory cytokine ,  nitrogen heterocyclic compound ,  urea compound ,  hydroxy compound
Semi thesaurus term： 炎症反応 ,  *インフラマソーム , 【Automatic Indexing@JST】

Author keywords (5)： gout ,  monosodium urate (MSU) ,  NLRP3 inflammasome ,  interleukin-1β ,  natural producct

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Musculoskeletal diseases  (GG03000T)

Substance index (1)： Uric Acid

Reference (55)：

• AmaralF. A., CostaV. V., TavaresL. D., SachsD., CoelhoF. M., FagundesC. T., et al (2012). NLRP3 Inflammasome-Mediated Neutrophil Recruitment and Hypernociception Depend on Leukotriene B(4) in a Murine Model of Gout. Arthritis Rheum. 64, 474-484. doi: 10.1002/art.33355
• BauernfeindF. G., HorvathG., StutzA., AlnemriE. S., MacdonaldK., SpeertD., et al (2009). Cutting Edge: NF-kappaB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression. J. Immunol. 183, 787-791. doi: 10.4049/jimmunol.0901363
• CasselS. L., EisenbarthS. C., IyerS. S., SadlerJ. J., ColegioO. R., TephlyL. A., et al (2008). The Nalp3 Inflammasome Is Essential for the Development of Silicosis. Proc. Natl. Acad. Sci. U S A. 105, 9035-9040. doi: 10.1073/pnas.0803933105
• ChoJ. H., JungJ. Y. (2015). Historical Study of the Etymological Form and Translational Process of Gout (Tongfeng,). Uisahak 24, 533-557. doi: 10.13081/kjmh.2015.24.533
• DalbethN., JonesG., TerkeltaubR., KhannaD., KopickoJ., BhaktaN., et al (2017). Lesinurad, a Selective Uric Acid Reabsorption Inhibitor, in Combination with Febuxostat in Patients with Tophaceous Gout: Findings of a Phase III Clinical Trial. Arthritis Rheumatol. 69, 1903-1913. doi: 10.1002/art.40159

Terms in the title (5)： NLRP3インフラマソーム ,  仲介 ,  痛風 ,  治療戦略 ,  天然物