Art

J-GLOBAL ID：202202260105720565   Reference number：22A2625009

KMT2A: Umbrella Gene for Multiple Diseases

KMT2A:多発性疾患に対するアンブレラ遺伝子【JST・京大機械翻訳】

Author (20)： Castiglioni Silvia (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Fede Elisabetta Di (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Bernardelli Clara (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Lettieri Antonella (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Lettieri Antonella (“Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Parodi Chiara (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Grazioli Paolo (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Colombo Elisa Adele (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Ancona Silvia (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Milani Donatella (Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita Degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy) ,  Ottaviano Emerenziana (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Borghi Elisa (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Massa Valentina (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Massa Valentina (“Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Ghelma Filippo (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Vignoli Aglaia (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Vignoli Aglaia (Child NeuroPsychiatry Unit, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy) ,  Lesma Elena (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Gervasini Cristina (Department of Health Sciences, Universita Degli Studi di Milano, 20142 Milan, Italy) ,  Gervasini Cristina (“Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, Universita Degli Studi di Milano, 20142 Milan, Italy)
Material： Genes (Web)
Volume： 13  Issue： 3  Page： 514  Publication year： 2022 
JST Material Number： U7194A  ISSN： 2073-4425  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： KMT2A (Lysine methyltransferas...

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Thesaurus term： methylation ,  *gene ,  chromatin ,  tumor ,  embryogenesis ,  histone ,  phenotype ,  methyltransferase ,  microflora ,  dysfunction ,  gene expression ,  *multiple disease ,  epigenetics ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  primary amine
Semi thesaurus term： 転写活性化 , 【Automatic Indexing@JST】

Author keywords (4)： KMT2A ,  chromatinopathies ,  tumors ,  epigenetics

JST classification (1)： Congenital diseases,deformities in general.  (GD03010V)

Substance index (1)： Lysine

Reference (103)：

• Kouzarides, T. Chromatin Modifications and Their Function. Cell 2007, 128, 693-705.
• Black, J.C.; Van Rechem, C.; Whetstine, J.R. Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact. Mol. Cell 2012, 48, 491-507.
• Garcia, B.A.; Hake, S.B.; Diaz, R.L.; Kauer, M.; Morris, S.A.; Recht, J.; Shabanowitz, J.; Mishra, N.; Strahl, B.D.; Allis, C.D.; et al. Organismal Differences in Post-Translational Modifications in Histones H3 and H4. J. Biol. Chem. 2007, 282, 7641-7655.
• Trojer, P.; Zhang, J.; Yonezawa, M.; Schmidt, A.; Zheng, H.; Jenuwein, T.; Reinberg, D. Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-Containing JMJD2/KDM4 Proteins. J. Biol. Chem. 2009, 284, 8395-8405.
• Daujat, S.; Weiss, T.; Mohn, F.; Lange, U.C.; Ziegler-Birling, C.; Zeissler, U.; Lappe, M.; Schübeler, D.; Torres-Padilla, M.E.; Schneider, R. H3K64 Trimethylation Marks Heterochromatin and Is Dynamically Remodeled during Developmental Reprogramming. Nat. Struct. Mol. Biol. 2009, 16, 777-781.

Terms in the title (3)： 多発性疾患 ,  アンブレラ ,  遺伝子