Art

J-GLOBAL ID：202202267203051435   Reference number：22A1316178

A Bacterially Expressed SARS-CoV-2 Receptor Binding Domain Fused With Cross-Reacting Material 197 A-Domain Elicits High Level of Neutralizing Antibodies in Mice

交差反応物質197Aドメインと融合した細菌発現SARS-CoV-2受容体結合ドメインはマウスにおける高レベルの中和抗体を誘導する【JST・京大機械翻訳】

Author (40)： Liu Liqin (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Liu Liqin (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Chen Tingting (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Chen Tingting (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Zhou Lizhi (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Zhou Lizhi (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Sun Jie (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Sun Jie (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Li Yuqian (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Li Yuqian (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Nie Meifeng (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Nie Meifeng (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Xiong Hualong (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Xiong Hualong (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Zhu Yuhe (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Zhu Yuhe (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Xue Wenhui (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Xue Wenhui (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Wu Yangtao (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Wu Yangtao (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Li Tingting (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Li Tingting (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Zhang Tianying (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Zhang Tianying (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Kong Zhibo (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Kong Zhibo (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Yu Hai (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Yu Hai (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Zhang Jun (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Zhang Jun (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Gu Ying (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Gu Ying (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Zheng Qingbing (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Zheng Qingbing (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Zhao Qinjian (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Zhao Qinjian (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Xia Ningshao (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Xia Ningshao (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China) ,  Li Shaowei (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China) ,  Li Shaowei (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China)
Material： Frontiers in Microbiology (Web)
Volume： 13  Page： 854630  Publication year： 2022 
JST Material Number： U7080A  ISSN： 1664-302X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The Coronavirus disease 2019 (...

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Thesaurus term： aluminum ,  Escherichia coli ,  adjuvant ,  serum ,  *receptor ,  *mouse(animal) ,  vaccine ,  *binding site ,  public health ,  antibody titer ,  fusion protein ,  *neutralization ,  *neutralizing antibody
Semi thesaurus term： *重症急性呼吸器症候群 ,  *交差反応 , 【Automatic Indexing@JST】

Author keywords (6)： SARS-CoV-2 ,  receptor binding domain ,  CRM197 A domain ,  Escherichia coli expression system ,  adjuvant ,  vaccine

JST classification (2)： Biochemistry of antigens,antibodies,complements  (ED04020L) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Reference (41)：

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• Chen W. H., Tao X., Agrawal A. S., Algaissi A., Peng B.-H., Pollet J., et al. (2020). Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement. Vaccine 38, 7533-7541. doi: , PMID: doi: 10.1016/j.vaccine.2020.09.061
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• Dai L., Zheng T., Xu K., Han Y., Xu L., Huang E., et al. (2020). A universal design of betacoronavirus vaccines against COVID-19, MERS, and SARS. Cell 182, 722.e11-733.e11. doi: , PMID: doi: 10.1016/j.cell.2020.06.035

Terms in the title (11)： 交差反応 ,  物質 ,  ドメイン ,  融合 ,  細菌発現 ,  SARS-CoV-2 ,  受容体結合 ,  マウス ,  高レベル ,  中和抗体 ,  誘導