Art

J-GLOBAL ID：202202281077070568   Reference number：22A2624781

Functional Validation of Osteoporosis Genetic Findings Using Small Fish Models

小魚モデルを用いた骨粗鬆症遺伝学的所見の機能的検証【JST・京大機械翻訳】

Author (2)： Kague Erika (School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK) ,  Karasik David (The Musculoskeletal Genetics Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel)
Material： Genes (Web)
Volume： 13  Issue： 2  Page： 279  Publication year： 2022 
JST Material Number： U7194A  ISSN： 2073-4425  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The advancement of human genom...

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Thesaurus term： biology ,  *heredity ,  gene ,  *Pisces ,  laboratory animal ,  mutant ,  human(primates) ,  genome ,  killifish ,  *genetics ,  Danio rerio ,  homology(characteristic) ,  *osteoporosis
Semi thesaurus term： 非翻訳領域 ,  動物モデル ,  ヒトゲノム , 【Automatic Indexing@JST】

Author keywords (8)： genome-wide association study ,  skeletal disease ,  gene regulation ,  causal gene ,  zebrafish ,  osteoblast ,  osteoclast ,  data integration

JST classification (3)： Congenital diseases,deformities in general.  (GD03010V) ,  Genetic variation  (EC01030Y) ,  Research methods in genetics  (EC01020N)

Reference (195)：

• Trajanoska, K.; Morris, J.A.; Oei, L.; Zheng, H.F.; Evans, D.M.; Kiel, D.P.; Ohlsson, C.; Richards, J.B.; Rivadeneira, F. Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study. BMJ 2018, 362, k3225.
• Odén, A.; McCloskey, E.V.; Kanis, J.A.; Harvey, N.; Johansson, H. Burden of high fracture probability worldwide: Secular increases 2010-2040. Osteoporos. Int. 2015, 26, 2243-2248.
• Younes, N.; Syed, N.; Yadav, S.K.; Haris, M.; Abdallah, A.M.; Abu-Madi, M. A Whole-Genome Sequencing Association Study of Low Bone Mineral Density Identifies New Susceptibility Loci in the Phase I Qatar Biobank Cohort. J. Pers. Med. 2021, 11, 34.
• Timpson, N.J.; Greenwood, C.M.; Soranzo, N.; Lawson, D.J.; Richards, J.B. Genetic architecture: The shape of the genetic contribution to human traits and disease. Nat. Rev. Genet. 2018, 19, 110-124.
• Karasik, D.; Myers, R.; Hannan, M.T.; Gagnon, D.; McLean, R.R.; Cupples, L.A.; Kiel, D. Mapping of Quantitative Ultrasound of the Calcaneus Bone to Chromosome 1 by Genome-Wide Linkage Analysis. Osteoporos. Int. 2002, 13, 796-802.

Terms in the title (6)： 小魚 ,  モデル ,  骨粗鬆症 ,  遺伝学 ,  所見 ,  検証