Art

J-GLOBAL ID：202202291974765966   Reference number：22A0378086

Pre-Steady-State Kinetics of the SARS-CoV-2 Main Protease as a Powerful Tool for Antiviral Drug Discovery

抗ウイルス薬発見の強力なツールとしてのSARS-CoV-2主要プロテアーゼの前定常状態速度論【JST・京大機械翻訳】

Author (28)： Zakharova Maria Yu. (Institute of Bioorganic Chemistry, Russian Academy of Sciences (RAS), Moscow, Russia) ,  Zakharova Maria Yu. (Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia) ,  Kuznetsova Alexandra A. (Institute of Chemical Biology and Fundamental Medicine, Siberian Branch (SB) of RAS, Novosibirsk, Russia) ,  Uvarova Victoria I. (FSASI “Chumakov FSC R&D IBP RAS” (Institute of Poliomyelitis), Moscow, Russia) ,  Fomina Anastasiia D. (FSASI “Chumakov FSC R&D IBP RAS” (Institute of Poliomyelitis), Moscow, Russia) ,  Fomina Anastasiia D. (Lomonosov Moscow State University, Moscow, Russia) ,  Kozlovskaya Liubov I. (FSASI “Chumakov FSC R&D IBP RAS” (Institute of Poliomyelitis), Moscow, Russia) ,  Kozlovskaya Liubov I. (Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia) ,  Kaliberda Elena N. (Institute of Bioorganic Chemistry, Russian Academy of Sciences (RAS), Moscow, Russia) ,  Kurbatskaia Inna N. (Institute of Bioorganic Chemistry, Russian Academy of Sciences (RAS), Moscow, Russia) ,  Smirnov Ivan V. (Institute of Bioorganic Chemistry, Russian Academy of Sciences (RAS), Moscow, Russia) ,  Smirnov Ivan V. (Lomonosov Moscow State University, Moscow, Russia) ,  Bulygin Anatoly A. (Institute of Chemical Biology and Fundamental Medicine, Siberian Branch (SB) of RAS, Novosibirsk, Russia) ,  Knorre Vera D. (Institute of Bioorganic Chemistry, Russian Academy of Sciences (RAS), Moscow, Russia) ,  Fedorova Olga S. (Institute of Chemical Biology and Fundamental Medicine, Siberian Branch (SB) of RAS, Novosibirsk, Russia) ,  Varnek Alexandre (Laboratoire de Chemoinformatique, UMR 7140 CNRS, Universite de Strasbourg, Strasbourg, France) ,  Osolodkin Dmitry I. (FSASI “Chumakov FSC R&D IBP RAS” (Institute of Poliomyelitis), Moscow, Russia) ,  Osolodkin Dmitry I. (Lomonosov Moscow State University, Moscow, Russia) ,  Osolodkin Dmitry I. (Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia) ,  Ishmukhametov Aydar A. (FSASI “Chumakov FSC R&D IBP RAS” (Institute of Poliomyelitis), Moscow, Russia) ,  Ishmukhametov Aydar A. (Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia) ,  Egorov Alexey M. (FSASI “Chumakov FSC R&D IBP RAS” (Institute of Poliomyelitis), Moscow, Russia) ,  Egorov Alexey M. (Lomonosov Moscow State University, Moscow, Russia) ,  Gabibov Alexander G. (Institute of Bioorganic Chemistry, Russian Academy of Sciences (RAS), Moscow, Russia) ,  Gabibov Alexander G. (Lomonosov Moscow State University, Moscow, Russia) ,  Gabibov Alexander G. (Department of Biology and Biotechnology, Higher School of Economics, Moscow, Russia) ,  Kuznetsov Nikita A. (Institute of Chemical Biology and Fundamental Medicine, Siberian Branch (SB) of RAS, Novosibirsk, Russia) ,  Kuznetsov Nikita A. (Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russia)
Material： Frontiers in Pharmacology (Web)
Volume： 12  Page： 773198  Publication year： 2021 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The design of effective target...

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Thesaurus term： interaction ,  steric conformation ,  enzyme ,  conformational transition ,  peptide ,  substrate(biochemistry) ,  *antiviral drug ,  active site ,  complex(substance) ,  *peptide bond hydrolase ,  viral replication ,  covalent bond ,  screening(inspection) ,  wild type
Semi thesaurus term： 非共有結合 , 【Automatic Indexing@JST】

Author keywords (7)： SARS-CoV-2 ,  main protease ,  pre-steady-state kinetics ,  substrate cleavage ,  inhibitor binding ,  molecular docking ,  stopped-flow

JST classification (3)： Virus biochemistry  (EG04030F) ,  Basic research of antiviral drugs  (GW17040O) ,  Enzyme in general  (EB09010D)

Reference (66)：

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Terms in the title (6)： 抗ウイルス薬 ,  発見 ,  ツール ,  SARS-CoV-2 ,  プロテアーゼ ,  定常状態速度論