Pat

J-GLOBAL ID：202203004256195155

広義原発開放隅角緑内障の発症リスクの判定方法

Inventor： 田代 啓 ,  木下 茂 ,  森 和彦 ,  池田 陽子 ,  上野 盛夫 ,  中野 正和 ,  吉井 健悟
Applicant, Patent owner： 京都府公立大学法人 ,  シスメックス株式会社 ,  参天製薬株式会社
Agent (1)： 細田 芳徳
Gazette classification：特許公報
Application number (International application number)：7022157
Patent number：7072803
Application date： Jun. 15, 2017
Claim (excerpt)：

【請求項1】 被検者から採取した生体試料における一塩基多型(SNP)のアレル情報に基づいて、12個のSNPからなるコアSNP群と、471個のSNPからなるプールSNP群から選ばれるSNP(プール選抜SNP群)とを合わせて少なくとも30個のSNPについて、アレルを測定するアレル測定工程、前記アレルの測定結果に基づいて、前記被検者における広義原発開放隅角緑内障の発症リスクに関する情報を取得する情報取得工程、及び前記で得られた情報に基づいて、前記被検者の広義原発開放隅角緑内障の発症リスクを判定するための情報を提供する情報提供工程を含む、被検者の広義原発開放隅角緑内障の発症リスクの診断を補助する方法であって、前記情報提供工程が、前記情報取得工程により得られた被検者に関する結果が、アレル測定工程で用いられたSNPに基づいて予め定められたカットオフ値を、上回る場合は前記被検者が広義原発開放隅角緑内障を発症するリスクが高く、下回る場合は前記被検者が広義原発開放隅角緑内障を発症するリスクが低いとの情報を提供するステップを含む工程であり、前記コアSNP群の12個のSNPが、rs7623847、rs11159830、rs4852079、rs10853035、rs7531982、rs4430527、rs1399216、rs12437660、rs9442、rs1149332、rs11136906及びrs11956913であり、前記プールSNP群の471個のSNPが、rs6429703、rs659046、rs11583644、rs835337、rs960501、rs3768184、rs6669702、rs2786755、rs1469876、rs2039153、rs12048011、rs9661521、rs7516960、rs515194、rs1127313、rs2661275、rs7524938、rs16852409、rs7367640、rs12026361、rs4233520、rs16850250、rs2841385、rs16855905、rs17313689、rs11680265、rs12615616、rs9332420、rs4344916、rs10490195、rs12713615、rs17030916、rs2587702、rs1529292、rs6747239、rs12477346、rs13408246、rs1627497、rs10804383、rs4973518、rs940947、rs9878659、rs2437685、rs1993761、rs6779858、rs775779、rs775722、rs162871、rs1993802、rs1462793、rs4450855、rs9866028、rs7644682、rs1499787、rs9874964、rs7378503、rs7656362、rs956469、rs11945500、rs4295245、rs6814828、rs6837917、rs6847630、rs7664412、rs13132427、rs1047626、rs2581441、rs7677091、rs13149904、rs12641050、rs2036455、rs10011515、rs6835198、rs1392874、rs2567388、rs12641140、rs10049967、rs13118455、rs2675531、rs261133、rs261162、rs1501958、rs4701849、rs835136、rs865036、rs9688120、rs4354048、rs12659589、rs6883614、rs10051972、rs17585205、rs27311、rs13168430、rs17165576、rs6875282、rs17097145、rs7744710、rs197962、rs197963、rs2815019、rs4311505、rs11968166、rs1518516、rs4895745、rs7753862、rs1873329、rs9493858、rs9376182、rs646695、rs4394230、rs4535568、rs311330、rs311329、rs4870148、rs9480313、rs6908330、rs2350842、rs2350835、rs13236851、rs7777579、rs7781607、rs7788738、rs10282694、rs1123227、rs879965、rs17152102、rs6968827、rs6943901、rs1015573、rs12698976、rs10271370、rs2079162、rs10215082、rs1476446、rs6466117、rs2267889、rs6959243、rs4725651、rs3779853、rs4876223、rs12548247、rs4457353、rs2440396、rs17077154、rs1079326、rs11988880、rs11786580、rs17250119、rs2853236、rs13248227、rs729005、rs16929、rs273393、rs2221770、rs7009780、rs10815523、rs1331260、rs10815020、rs10974623、rs10974624、rs4742008、rs301430、rs4742011、rs10120677、rs1890074、rs4448374、rs10965215、rs564398、rs10757270、rs10757272、rs4977574、rs2891168、rs1333042、rs815845、rs2798062、rs1777052、rs6479594、rs290221、rs1755938、rs16936272、rs563、rs1130635、rs3812591、rs7919331、rs11254023、rs11254057、rs6602142、rs12218350、rs11008621、rs6481756、rs2808068、rs10762738、rs7896131、rs7090670、rs7901883、rs2419836、rs1907220、rs17663978、rs10901799、rs11016590、rs7113375、rs12291056、rs4755436、rs10838418、rs17788930、rs656104、rs17286033、rs2640785、rs1056136、rs582146、rs575848、rs11603786、rs2343877、rs1049376、rs2570、rs7973582、rs11049085、rs12370473、rs4931245、rs929952、rs7980789、rs1729803、rs11178499、rs2137506、rs12580741、rs1526844、rs10861463、rs4293219、rs1009438、rs10773249、rs10847208、rs17083838、rs1322569、rs6563805、rs9532536、rs10492606、rs4942888、rs1413065、rs9564019、rs2134897、rs1965830、rs9514234、rs9587525、rs2179931、rs179562、rs179558、rs397080、rs761509、rs1450709、rs10133218、rs941714、rs941713、rs4417522、rs683922、rs1568679、rs8023369、rs4775035、rs11632583、rs1482929、rs922878、rs1482933、rs2672086、rs12441915、rs4338756、rs11633107、rs2015808、rs12903810、rs2667675、rs1029442、rs12599165、rs6497609、rs11649409、rs1424151、rs1056321、rs12451094、rs8070213、rs181535、rs9890602、rs7224525、rs12452064、rs199494、rs11079884、rs1003313、rs4476235、rs8075920、rs16976552、rs544748、rs891805、rs2269222、rs7234150、rs11659375、rs8085116、rs996919、rs11150、rs216283、rs1368456、rs2734456、rs2734454、rs2965106、rs6135852、rs8126205、rs6119304、rs6102788、rs2235862、rs4811206、rs3810550、rs6142738、rs2427293、rs735501、rs3003137、rs1543766、rs2839504、rs130414、rs4648462、rs1459764、rs10917476、rs666371、rs16828286、rs835340、rs4915844、rs9970705、rs11209252、rs1361493、rs7516969、rs1698598、rs1890303、rs6700410、rs41467544、rs7540764、rs11811532、rs17016333、rs6756667、rs11903594、rs2587693、rs7583123、rs17685106、rs896790、rs1441456、rs13007054、rs12989659、rs11901692、rs2727946、rs17234276、rs1558893、rs6766740、rs826431、rs4130090、rs844438、rs17069212、rs1502757、rs9871957、rs16849435、rs9815106、rs879394、rs6449420、rs16869447、rs2660341、rs6840349、rs17026134、rs2567372、rs41330746、rs3775851、rs1113890、rs8180155、rs3094356、rs386313、rs2973092、rs10514994、rs7729566、rs30997、rs6897211、rs409855、rs7705024、rs364211、rs13360374、rs7726729、rs17056003、rs7754459、rs4711718、rs7760603、rs1150093、rs4710773、rs4722237、rs788761、rs13311390、rs12718634、rs820935、rs10487463、rs3112341、rs4875712、rs10106492、rs3020282、rs11250152、rs4872203、rs17652451、rs3739231、rs10974620、rs3780411、rs9632884、rs2798058、rs1777035、rs2798042、rs290226、rs573212、rs12339593、rs16929114、rs3124596、rs7099056、rs7922576、rs2688812、rs2688815、rs11199835、rs17104935、rs3781452、rs10159505、rs2057498、rs7107896、rs10769120、rs4752797、rs7120194、rs10502071、rs604411、rs7960985、rs4764380、rs863786、rs11177371、rs1512979、rs12230997、rs7990612、rs12018544、rs9315894、rs1588681、rs421841、rs9529485、rs8000868、rs179541、rs763388、rs10142332、rs4924127、rs17239763、rs14912、rs967180、rs2283462、rs1032955、rs12917583、rs3751664、rs757166、rs757164、rs16956781、rs10852333、rs12600303、rs4784219、rs12597838、rs9889056、rs6502937、rs4969326、rs1786809、rs11663052、rs16971109、rs17787324、rs4599012、rs12458940、rs7250638、rs1407033、rs2235863、rs3746417、rs7278259、rs5996894、rs138679、rs1894469及びrs5764733である、被検者の広義原発開放隅角緑内障の発症リスクの診断を補助する方法。

IPC (4)：

C12Q 1/68 ( 201 8.01) ,  C12M 1/00 ( 200 6.01) ,  G01N 33/53 ( 200 6.01) ,  C12N 15/09 ( 200 6.01)

FI (4)：

C12Q 1/68 ZNA ,  C12M 1/00 A ,  G01N 33/53 M ,  C12N 15/09 Z