Tanaka Rinako

タナカリナコ | Tanaka Rinako

Affiliation and department：
Job title： Program-Specific Assistant Professor

Research field (2)： Pharmacology , Pharmacology

Research keywords (3)：薬理学 , 統合失調症 , 行動薬理学

Research theme for competitive and other funds (4)：

2024 - 2027 ゲノム解析を基盤とした統合失調症モデルマウスを用いた体性感覚異常のメカニズム解明
2023 - 2025 統合失調症患者のゲノム解析を基盤とした新規治療戦略の創生
2023 - 2023 Fasudil ameliorates methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated gene mutations in the Arhgap10 gene
2021 - 2023 統合失調症の病態解明に向けたArhgap10遺伝子変異マウスの神経機能の解析

Papers (4)：

Rinako Tanaka, Jingzhu Liao, Yue Liu, Wenjun Zhu, Kisa Fukuzawa, Masamichi Kondo, Masahito Sawahata, Daisuke Mori, Akihiro Mouri, Hisayoshi Kubota, et al. Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia. bioRxiv. 2024
Rinako Tanaka, Kiyofumi Yamada. Genomic and Reverse Translational Analysis Discloses a Role for Small GTPase RhoA Signaling in the Pathogenesis of Schizophrenia: Rho-Kinase as a Novel Drug Target. International journal of molecular sciences. 2023. 24. 21
Rinako Tanaka, Jingzhu Liao, Kazuhiro Hada, Daisuke Mori, Taku Nagai, Tetsuo Matsuzaki, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, et al. Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene. Pharmacological Research. 2023. 187. 106589-106589
Saeko Takase, Jingzhu Liao, Yue Liu, Rinako Tanaka, Yasuhiro Miyagawa, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Taku Nagai, Kozo Kaibuchi, et al. Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. European Journal of Pharmacology. 2022. 931. 175207-175207

MISC (4)：

Rinako Tanaka, Jingzhu Liao, Daisuke Mori, Taku Nagai, Tetsuo Matsuzaki, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada. Neuropharmacology. British Journal of Pharmacology. 2023. 180. S1. 1004-1004
Tanaka Rinako, Zhu Wenjun, Mori Daisuke, Mouri Akihiro, Nagai Taku, Nabeshima Toshitaka, Kaibuchi Kozo, Tachibana Daiki, Kobayashi Yohei, Ozaki Norio, et al. Selective Rho-kinase 2 inhibitor ameliorates the decreased spine density in the medial prefrontal cortex of mice carrying the variants of Arhgap10 gene found in a Japanese schizophrenia patient. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023. 97. 1-B-YIA2-5
Tanaka Rinako, Hada Kazuhiro, Mizoguchi Hiroyuki, Sawahata Masahito, Nagai Taku, Mori Daisuke, Nabeshima Toshitaka, Kaibuchi Kozo, Ozaki Norio, Yamada Kiyofumi. Establishment of an in vivo calcium imaging method to evaluate neuronal activity in mice carrying mutations of Arhgap10 gene. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 2-P-168
Tanaka Rinako, Sawahata Masahito, Takase Saeko, Liu Yue, Hada Kazuhiro, Mizoguchi Hiroyuki, Nagai Taku, Nabeshima Toshitaka, Ozaki Norio, Yamada Kiyofumi. Effects of a Rho-kinase inhibitor, fasudil on schizophrenia-like behavior and neurotransmitter release in MK-801-treated mice. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 1-Y-F3-4

Books (1)：

Lectures and oral presentations (10)：

統合失調症の新規治療薬候補であるRho-kinase 2選択的阻害薬KD025は錐体外路症状及び高プロラクチン血症を誘発しない
(第25回応用薬理シンポジウム 2024)
A Rho-kinase 2 selective inhibitor KD025 ameliorates schizophrenia-like behaviors in MK-801-treated mice
(35th WORLD CONGRESS World Congress Collegium Internationale Neuro-Psychopharmacologicum 2024)
Selective Rho-kinase 2 inhibitor ameliorates the decreased spine density in the medial prefrontal cortex of mice carrying the variants of Arhgap10 gene found in a Japanese schizophrenia patient
(2023)
Fasudil ameliorates methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated gene mutations in the Arhgap10 gene
(19th World Congress of Basic & Clinical Pharmacology 2023 2023)
Establishment of an in vivo calcium imaging method to evaluate neuronal activity in mice carrying mutations of Arhgap10 gene
(2022)

ｍore...

Education (2)：

Professional career (1)：

Work history (1)：

Awards (5)：

2024/10 - 応用薬理研究会優秀ポスター賞統合失調症の新規治療薬候補であるRho-kinase 2選択的阻害薬KD025は錐体外路症状及び高プロラクチン血症を誘発しない
2024/05 - Japanese Society of Neuropsychopharmacology JSNP Excellent Presentation Award for CINP 2024 A Rho-kinase 2 selective inhibitor KD025 ameliorates schizophrenia-like behaviors in MK-801-treated mice
2021/10 - 日本神経精神薬理学会鍋島賞
2021/10 - 日本神経精神薬理学会 JSNP Excellent Presentation Award for AsCNP 2021
2021/06 - ePoster Best Presentation Award Effect of fasudil in a pharmacologic animal model of schizophrenia

Association Membership(s) (3)：

Society of Neuroscience , 日本神経精神薬理学会 , 日本薬理学会

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