Rchr
J-GLOBAL ID：202301004550668916
Update date: Nov. 19, 2025
Mizutani Natsuki
ミズタニ ナツキ | Mizutani Natsuki
Affiliation and department：
Job title：
Assistant Professor
Research field (2)：
Physiology
, Bio-, chemical, and soft-matter physics
Research keywords (5)：
Voltage-sensing phosphatase
, Ion Channel
, Electrophysiology
, Physiology
, X-ray crystallography
Research theme for competitive and other funds (2)：
- 2024 - 2027 X線結晶構造解析による電位感受性酵素VSPの分子メカニズム解明
- 2023 - 2025 電位感受性酵素VSPの膜環境マルチセンシング機構の解明
Papers (10)：
-
Junxian Zhou, Rizki Tsari Andriani, Natsuki Mizutani, Kohei Yamamoto, Daisuke Yoshioka, Akira Kawanabe, Takafumi Kawai, Yoshifumi Okochi, Yasushi Okamura. Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue. Journal of General Physiology. 2025. 158. 1. e202513811
-
Natsuki Mizutani, Yasushige Yonezawa, Atsushi Nakagawa, Yasushi Okamura. Nonsubstrate PI(4,5)P 2 interacts with the interdomain linker to control electrochemical coupling in voltage-sensing phosphatase (VSP). Proceedings of the National Academy of Sciences. 2025. 122. 31. e2500651122
-
Takafumi Kawai, Natsuki Mizutani, Yasushi Okamura. Voltage- and Ca2+-inducible PLC activity for analyzing PI(4,5)P2 sensitivity of ion channels in Xenopus oocytes. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2025. 1867. 1. 184396
-
Hidekazu Tsutsui, Yuka Jinno, Natsuki Mizutani, Yasushi Okamura. Structural change of the cytoplasmic N-terminus and S1 segment of voltage-sensing phosphatase reported by Anap. Acta Physiologica. 2024. 240. 5. e14137
-
Ian Costa Paixao, Natsuki Mizutani, Makoto Matsuda, Rizki Tsari Andriani, Takafumi Kawai, Atsushi Nakagawa, Yoshifumi Okochi, Yasushi Okamura. Role of K364 next to the active site cysteine in voltage-dependent phosphatase activity of Ci-VSP. Biophysical Journal. 2023. 122. 11. 2267-2284
ｍore...
MISC (1)：
-
水谷夏希, 二井手哲平, 清水浩, 岡村康司. AI解析を足掛かりとした電位依存性ホスファターゼVSPの基質特異性形成機構の解明. 日本生化学会大会(Web). 2023. 96th
Lectures and oral presentations (11)：
-
Non-substrate PI(4,5)P2 interaction regulates voltage-sensing phosphatase (VSP)
(40th Congress of the International Union of Physiological Sciences (IUPS 2025) in partnership with Europhysiology 2025)
-
AI-based approach to identification of residues underlying substrate specificity of voltage-sensing phosphatase (VSP) distinct from PTEN
(APPW2025 2025)
-
Phospholipid modulation of transduction from electrical signal to chemical one in voltage-sensing phosphatase (VSP).
(The 52nd Naito Conference 2024)
-
Analysis of the role of interactions between voltage-sensing phosphatase (VSP) and PI(4,5)P2 in electro-chemical signal transduction of VSP
(The 101st Annual Meeting of The Physiological Society of Japan 2024)
-
Fluorometric analysis of the interactions between voltage-sensing phosphatase (VSP) and PI(4,5)P2
(68th Biophysical Society Annual Meeting 2024)
ｍore...
Education (3)：
- 2019 - 2023 Osaka University Graduate School of Medicine
- 2017 - 2019 Osaka University Graduate School of Medicine
- 2012 - 2016 Fujita Health University
Professional career (1)：
- Ph.D. (Medicine) (Osaka University)
Work history (6)：
Committee career (1)：
- 2024/04 - 現在 The Physiological Society of Japan Councillor
Awards (3)：
- 2023/03 - 大阪大学大学院医学系研究科 山村賞
- 2020/02 - Biophysical Society Student Research Achievement Award
- 2019/03 - FAOPS2019 Journal of General Physiology Poster Award
Association Membership(s) (3)：
Japanese Biochemical Society
, Biophysical Society
, Physiological Society of Japan
