Rchr
J-GLOBAL ID：202301005924704039
Update date: Nov. 19, 2024
Obita Takayuki
オビタ タカユキ | Obita Takayuki
Affiliation and department：
Job title：
Associate professor
Research theme for competitive and other funds (10)：
- 2022 - 2025 自然免疫に重要なcGASを活性化するZCCHC3の作用機構の解明
- 2020 - 2023 Structural study of pro-filaggrin recognition by SASPase
- 2019 - 2022 How does PQBP1 suppress the induction of type I interferon expression by cGAS?
- 2016 - 2019 Structural Study of basal transcription factor TFIIE
- 2015 - 2018 Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1
- 2014 - 2016 Structural basis of Archaeal ESCRT complex
- 2012 - 2015 Verification of the connector function of the transcription and splicing factor PQBP1
- 2012 - 2014 Structural basis of the filament formation of ESCRT-III proteins
- 2010 - 2011 A structural study towards the understanding of the roles of Archaeal ESCRT in cell division.
- 2004 - 2006 ミトコンドリア・プレ配列レセプターTom20によるプレ配列認識の構造的基盤
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Papers (40)：
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Tomonao Inobe, Runa Sakaguchi, Takayuki Obita, Atushi Mukaiyama, Seiichi Koike, Takeshi Yokoyama, Mineyuki Mizuguchi, Shuji Akiyama. Structural insights into rapamycin-induced oligomerization of a FRB-FKBP fusion protein. FEBS Letters. 2024
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Mineyuki Mizuguchi, Niko Kyan, Suzuka Nishimata, Yuko Nabeshima, Takayuki Obita. Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA. Bioscience reports. 2024. 44. 4
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Mineyuki Mizuguchi, Takayuki Obita, Seiya Yamada, Yuko Nabeshima. Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis. The FEBS journal. 2024. 291. 8. 1732-1743
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Takuya Okada, Kaho Yamabe, Michiko Jo, Yuko Sakajiri, Tomokazu Shibata, Ryusuke Sawada, Yoshihiro Yamanishi, Daisuke Kanayama, Hisashi Mori, Mineyuki Mizuguchi, et al. Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity. Bioorganic & medicinal chemistry letters. 2023. 93. 129438-129438
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Michiko Jo, Keiichi Koizumi, Mizuho Suzuki, Daisuke Kanayama, Yurie Watanabe, Hiroaki Gouda, Hisashi Mori, Mineyuki Mizuguchi, Takayuki Obita, Yuko Nabeshima, et al. Design, synthesis, structure-activity relationship studies, and evaluation of novel GLS1 inhibitors. Bioorganic & medicinal chemistry letters. 2023. 87. 129266-129266
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MISC (1)：
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帯田 孝之, 三輪 康平, 小島 理恵子, 大熊 芳明, 田村 康, 水口 峰之. 基本転写因子TFIIEの構造生物学的研究. 生命科学系学会合同年次大会. 2017. 2017年度. [2P-0076]
Patents (2)：
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