Research keywords (7):
DNA nanotechnology
, atomic force microscopy
, RNA modification
, transfer RNA
, decoding machinery
, molecular machine
, DNA origami
Research theme for competitive and other funds (10):
2023 - 2025 Hierarchical Self-Assembly of 2D DNA Platform for Multiscale Nanoarray
2023 - 2025 Universal and Modular Molecular Motor for DNA nanodevices
2021 - 2024 dna-origami-db for automation of DNA origami research
2022 - 2023 Multiplex nucleic acid detection method enabled by DNA origami and artificial metabolism
2021 - 2023 Sensitive and Specific Long RNA Detecting Nanodevice for Future Lab-Test Diagnosis
2021 - 2023 Universal Molecular Motor for DNA nanorobot
2020 - 2020 Single molecule imaging of DNA gyrase activity on DNA origami
2019 - 2019 Single molecule imaging of DNA gyrase activity on DNA origami (Summer School)
2017 - 2019 Drug delivery and activation system with DNA origami robotics
2013 - 2016 The biogenesis of 5-hydroxyuridine observed in wobble position of Escherichia coli tRNA
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Papers (12):
Gerrit D. Wilkens, Piotr Stępień, Yusuke Sakai, Md. Sirajul Islam, Jonathan G. Heddle. A DNA Origami Bubble Blower for Liposome Production. ACS Omega. 2024
Yusuke Sakai, Gerrit D. Wilkens, Karol Wolski, Szczepan Zapotoczny, Jonathan G. Heddle. Topogami: Topologically Linked DNA Origami. ACS Nanoscience Au. 2022. 2. 1. 57-63
Shiu, S.C.-C., Sakai, Y., Tanner, J.A., Heddle, J.G. Fret-mediated observation of protein-triggered conformational changes in dna nanostructures. Methods in Molecular Biology. 2021. 2208. 69-80
Sakai, Y., Kimura, S., Suzuki, T. Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability. Nature Communications. 2019. 10. 1. 2858
Sakai, Y., Islam, M.S., Adamiak, M., Shiu, S.C.-C., Tanner, J.A., Heddle, J.G. DNA aptamers for the functionalisation of DNA origami nanostructures. Genes. 2018. 9. 12. 571-571
2021/11 - 5th Annual Meeting of Molecular Robotics Japan Young researcher award (Poster award) Enzymatic catenation of long DNA for "Topogami" (translate)
2019/07 - FEBS Letter Daily Poster Award DNA origami nanocapsules for controllable cargo accessibility.
2017/02 - Horizon 2020 Marie Sklodowska-Curie Actions Seal of Excellence
2015/12 - Oxford University Press NAR Breakthrough Article Biogenesis and growth phase-dependent alteration of 5-methoxycarbonylmethoxyuridine in tRNA anticodons
Association Membership(s) (4):
Chemical Society of Japan
, Chem-Bio Informatics Society
, 日本生物物理学会
, The Society of Instrument and Control Engineers