Rchr
J-GLOBAL ID：202301006747783736
Update date: Nov. 20, 2023
Kume Shinichiro
クメ シンイチロウ | Kume Shinichiro
Affiliation and department：
Job title：
Assistant Professor
Research field (2)：
Molecular biology
, Applied molecular and cellular biology
Research keywords (3)：
Ion channel
, Molecular Biology
, Electrophysiology
Research theme for competitive and other funds (3)：
- 2021 - 2024 Analyses of the gating mechanisms based on the Non-domain swapped architecture of the hERG channel
- 2019 - 2023 Analyses of the structure-function relationship based on the characteristic interaction among the intracellular domains in the hERG channel
- 2017 - 2020 The analyses of the interaction between the intracellular domains to control the slow deactivation of hERG channel
Papers (8)：
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Mengyan Wei, Pu Wang, Xiufang Zhu, Masaki Morishima, Yangong Liu, Mingqi Zheng, Gang Liu, Hiroki Osanai, Kenshi Yoshimura, Shinichiro Kume, et al. Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel. PloS one. 2023. 18. 2. e0280656
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Pu Wang, Mengyan Wei, Xiufang Zhu, Yangong Liu, Kenshi Yoshimura, Mingqi Zheng, Gang Liu, Shinichiro Kume, Masaki Morishima, Tatsuki Kurokawa, et al. Nitric oxide down-regulates voltage-gated Na+ channel in cardiomyocytes possibly through S-nitrosylation-mediated signaling. Scientific reports. 2021. 11. 1. 11273-11273
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Pu Wang, Xiufang Zhu, Mengyan Wei, Yangong Liu, Kenshi Yoshimura, Mingqi Zheng, Gang Liu, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono. Disruption of asparagine-linked glycosylation to rescue and alter gating of the NaV1.5-Na+ channel. Heart and vessels. 2021. 36. 4. 589-596
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Yangong Liu, Pu Wang, Fangfang Ma, Mingqi Zheng, Gang Liu, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono. Asparagine-linked glycosylation modifies voltage-dependent gating properties of CaV3.1-T-type Ca2+ channel. The journal of physiological sciences : JPS. 2019. 69. 2. 335-343
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Shinichiro Kume, Takushi Shimomura, Michihiro Tateyama, Yoshihiro Kubo. Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain. The Journal of physiology. 2018. 596. 19. 4629-4650
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Association Membership(s) (3)：
Japanese Society of Pathophysiology
, The Japan Neuroscience Society
, The Physiological Society of Japan
