Rchr
J-GLOBAL ID：202301012914454421
Update date: Nov. 12, 2024
Murase Hirotaka
ムラセ ヒロタカ | Murase Hirotaka
Affiliation and department：
Job title：
Assistant Professor
Research field (2)：
Bioorganic chemistry
, Pharmaceuticals - chemistry and drug development
Research keywords (4)：
small molecules
, functionality oligonucleotides
, organic chemistry
, Nucleic Acids Chemistry
Research theme for competitive and other funds (5)：
- 2024 - 2027 Basic research into nucleic acid drugs that induce readthrough by chemically modifying the adenosine at the premature termination codon
- 2023 - 2026 シトシンN4位の部位特異的アシル基修飾法の開発
- 2021 - 2025 Development of small molecule drugs for fragile X syndrome based on ligands that cooperatively accumulate on the CGG repeats.
- 2020 - 2023 Development of small molecular ligands that bind to repeat RNA and induce a conformational change of RNA higher-order structure
- 2018 - 2020 Development of the recognition molecules for pre-miRNA based on the hydrogen bonding
Papers (19)：
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Hirotaka Murase, Mio Eto, Jeongsu Lee, Yosuke Taniguchi, Shuhei Imoto, Shigeki Sasaki. Site-specific acetyl modification of 2'-OH of RNA by an oligonucleotide acetylating reagent,. Chemical Communications. 2024. 60. 13440-13442
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Mami Ototake, Masahito Inagaki, Seigo Kimura, Kaoru Onda, Mizuki Tada, Daisuke Kawaguchi, Hirotaka Murase, Kosuke Fukuchi, Yinuo Gao, Kengo Kokubo, et al. Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA. Nucleic acids research. 2024. 52. 12141-12157
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Kohei Nomura, Seongjin An, Yoshiaki Kobayashi, Jiro Kondo, Ting Shi, Hirotaka Murase, Kosuke Nakamoto, Yasuaki Kimura, Naoko Abe, Kumiko Ui-Tei, et al. Synthesis of 2′-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs. Nucleic Acids Research. 2024. 52. 10754-10774
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Hirotaka Murase, Jeongsu Lee, Norihiro Togo, Yosuke Taniguchi, Shigeki Sasaki. The selective chemical modification of the 6-amino group of adenosine of the premature termination codon induces readthrough to produce full-length peptide in the reconstituted E. Coli translation system. Bioorganic & Medicinal Chemistry. 2024. 111. 117868-117868
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KOJI NISHI, RYO KANDA, KAHO TAKASAKI, AYANO TAMORI, YOSHIFUMI ARIMURA, SHUHEI IMOTO, HIROTAKA MURASE, KENJI TSUKIGAWA, MASAKI OTAGIRI, KEISHI YAMASAKI. Novel Diclofenac-NO Donor With High Affinity for Human Serum Albumin Induces Endoplasmic Reticulum Stress-mediated Cell Death in Human Pancreatic Cancer Cells. Anticancer Research. 2024. 44. 9. 3793-3798
ｍore...
MISC (3)：
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Sasaki, S., Murase, H. Manipulating nucleic acids-regulation of gene expression through higher order structure and chemical modification. Drug Delivery System. 2024. 39. 1. 53-62
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なし. 2022. 22. 177-185
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なし. Journal of the Japan Society of Nucleic Acids Chemistry. 2020. Vol. 4. 15-21
Lectures and oral presentations (97)：
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RNAの部位特異的アシル修飾を可能とする新規人工オリゴ核酸反応剤の開発
(第50回反応と合成の進歩シンポジウム 2024)
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2ʼ位化学修飾核酸の導入によるsiRNAの標的特異性の向上
(日本核酸医薬学会第9回年会 2024)
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Improvement of siRNA target specificity with a new 2'-modified nucleoside analog
(第25回日本RNA学会年会 2024)
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PCR停止プライマーによるDNA連結法の開発とmRNAライブラリー構築への応用
(日本ケミカルバイオロジー学会 第18回年会 2024)
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Synthesis of cap-2-type mRNA based on PureCap method
(The 3rd Intertnaional Symposium on Biofunctional Chemistry (ISBC2024) 2024)
ｍore...
Education (3)：
- 2014 - 2017 Kyushu University Graduate School, Division of Pharmaceutical Sciences
- 2012 - 2014 Kyushu University Graduate School, Division of Pharmaceutical Sciences
- 2008 - 2012 Kyushu University Faculty of Pharmaceutical Science
Professional career (1)：
- Ph.D. (Kyushu University)
Work history (4)：
- 2023/04 - 現在 Sojo University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
- 2020/06 - 2023/03 Nagasaki International University Faculty of Pharmaceutical Science Researher Postdoc
- 2019/01 - 2020/05 Nagoya University Graduate School, Division of Pharmaceutical Sciences Researher Postdoc
- 2017/04 - 2018/12 Tohoku University Institute of Multidisciplinary Research for Advanced Materials Researher Postdoc
Awards (1)：
- 2018/11 - The 45th international Symposium on Nucleic Acids Chemistry ISNAC Outstanding Oral Presentation Award for Young Scientist (Ohtsuka Award)
Association Membership(s) (3)：
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