Yari Shinya

ヤリシンヤ | Yari Shinya

Affiliation and department：
Job title： Research Fellow
Other affiliations (1)：

Harvard Medical School Research Fellow

Homepage URL (1)： https://wellman.massgeneral.org/charles_lin/people

Research field (4)： Physiology , Immunology , Hematology and oncology , Experimental pathology

Research keywords (6)： Hematopoietic Stem Cell , Microenvironment , Bone Metabolism , Osteoimmunology , Rheumatoid Arthritis , in vivo imaging

Research theme for competitive and other funds (3)：

2023 - 2024 Elucidation of the mechanism of bone marrow microenvironment regulated by bone metabolism
2022 - 2024 Identification of a novel osteocyte subset responsible for bone remodeling and its functional characterization
2021 - 2022 生体イメージングを駆使した関節リウマチ薬JAK阻害剤のin vivo薬理評価

Papers (7)：

Takeshi Kaneko, Shinya Yari, Junichi Kikuta, Yoshiki Omatsu, Shigeto Seno, Sumire Kikuchi, Kazuma Sato, Kentaro Fujii, Takao Sudo, Tetsuo Hasegawa, et al. The RANK/RANKL axis controls vascular dynamics in the bone marrow. Proceedings of the National Academy of Sciences. 2025. 122. 45
Kotaro Shimizu, Junichi Kikuta, Yumi Ohta, Yutaka Uchida, Yu Miyamoto, Akito Morimoto, Shinya Yari, Takashi Sato, Takefumi Kamakura, Kazuo Oshima, et al. Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction. Nature Communications. 2023. 14. 1
Yari S, Kikuta J, Shigyo H, Miyamoto Y, Okuzaki D, Furusawa Y, Minoshima M, Kikuchi K, Masaru Ishii. JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors. Inflammation and regeneration. 2023. 43. 1
Takuya Koike, Kentaro Fujii, Kohei Kometani, Noah S. Butler, Kenji Funakoshi, Shinya Yari, Junichi Kikuta, Masaru Ishii, Tomohiro Kurosaki, Wataru Ise. Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow. Journal of Experimental Medicine. 2023. 220. 2
Agemura T, Hasegawa T, Yari S, Kikuta J, Masaru Ishii. Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion. Inflammation and regeneration. 2022. 42. 1

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MISC (13)：

Shinya Yari, Qi Yu, Debra Van Egeren, Christa Haase, Fernando Camargo, Charles Lin. 3165 - ELUCIDATING THE FATE OF INDIVIDUAL HEMATOPOIETIC STEM CELLS IN THE BONE MARROW. Experimental Hematology. 2025. 151. 105106-105106
Shinya Yari, Qi Yu, Debra Van Egeren, Christa Haase, Fernando D. Camargo, Charles P. Lin. Elucidation of spatial and clonal heterogeneity in HSC differentiation. JOURNAL OF BONE AND MINERAL RESEARCH. 2024. 39. 346-346
鎗伸弥, 菊田順一, 石井優. 骨組織の生体イメージング-Intravital imaging of bone tissues-特集新組織学シリーズ(4)骨・軟骨 ; 骨・軟骨組織の構造と細胞分化・機能. 生体の科学. 2023. 74. 6. 540-543
佐藤和真, 鎗伸弥, 菊田順一. Intravital imaging of bone and immune system. 医学のあゆみ. 2023. 286. 5. 392-398
三木初音, 吉村康孝, 蓑島維文, 鎗伸弥, 菊田順一, 石井優, 菊地和也. 骨組織pHを測定するレシオ蛍光イメージングプローブの開発. JSMI Report. 2023. 16. 2. 110-110

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Lectures and oral presentations (2)：

Image-seq enables image-guided cell isolation and uncovers the heterogenous hematopoiesis of individual HSCs
(ISEH 54th Annual Scientific Meeting (New Investigator Technology Session) 2025)
Elucidating the Fate of Individual Hematopoietic Stem Cells in the Bone Marrow
(ISEH 54th Annual Scientific Meeting (New Investigators Pre-Meeting Workshop) 2025)

Education (1)：

2019 - 2023 Osaka University Graduate School of Frontier Biosciences

Professional career (1)：

Ph.D. The University of Osaka Graduate School of Science (The University of Osaka)

Work history (4)：

2023/10 - 現在 Massachusetts General Hospital Center for Systems Biology Research Fellow
2023/10 - 現在 Harvard Medical School Research Fellow
2023/10 - 現在 Massachusetts General Hospital Wellman Center for Photomedicine Research Fellow
2022/04 - 2023/09 Japan Society for the Promotion of Science Research Fellowships for Young Scientists

Awards (4)：

2025 - ISEH 54th Annual Scientific Meeting Technology and Innovation Travel Grant
2025 - ASBMR 2025 Annual Meeting Young Investigator Travel Grant
2025 - ASBMR 2025 Annual Meeting Plenary Poster
2023 - Japan Society for the Promotion Science Overseas Challenge Program for Young Researchers

Association Membership(s) (5)：

International Society for Experimental Hematology , The Molecular Biology Society of Japan , The American Society for Bone and Mineral Research , Japanese Society of Osteoimmunology , The Japanese Society of Inflammation and Regeneration

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