Sekimizu Kazuhisa

セキミズカズヒサ | Sekimizu Kazuhisa

Affiliation and department：

Research keywords (1)： Drug discoveries with silkworms

Research theme for competitive and other funds (42)：

2021 - 2024 食品由来の強力な自然免疫活性化能を示す新規物質の作用機序解析
2017 - 2020 Comprehensive analysis of pathogenic ncRNA in host environment
2015 - 2020 Platform for the identification of novel therapeutically effective antimicrobial agents
2014 - 2017 Comprehensive understanding of bacterial adaptation mechanism in diabetic host
2013 - 2015 治療効果を指標に同定された新規抗菌薬の作用機序解析

2012 - 2014 新規リポペプチド系抗生物質カイコシンの標的同定

2012 - 2014 Establishment of screening system for antifungal drugs using silkworm fungus infection model

2011 - 2014 Understanding of host-pathogen interaction by using silkworm infection model

2009 - 2011 Development of novel molecular-targeted medicine against aminopeptidase

2009 - 2010 新規病原性遺伝子群を基盤とする病原性発現コアシステムの把握

2008 - 2010 Elucidation of bacterial pathogenesis system based on a silkworm infection model

2008 - 2009 肝細胞がん特有の進行メカニズムに着目した新規化学療法剤の開発

2007 - 2008 カイコ感染モデルを用いたグラム陽性細菌に保存された病原性発現機構の解明

2007 - 2007 黄色ブドウ球菌の滑走能低下を指標とした抗菌治療薬に関する研究

2005 - 2006 カイコ幼虫における薬物動態に関する研究

2003 - 2003 ヒトに対する病原性細菌の感染モデルとしてのカイコ幼虫の有用性に関する研究

2002 - 2003 Functions of transcription elongation factor S-II for cell stress response and development

2002 - 2003 マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学

2002 - 2002 マウス初期胚におけるDNAトポイソメラーゼII依存チェックポイント機能低下の可能性

2001 - 2001 マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学

2000 - 2001 消毒剤耐性変異の獲得に伴うMRSAのβラクタム系抗生物質耐性の上昇

2000 - 2001 Development of antibiotics by monitoring the inhibition of the ATP-binding to DnaA, the initiator protein of chromosomal DNA replication in bacteria

1999 - 2000 Study of the regulatory mechanism of DnaA protein, the initiator of DNA replication in Escherichia coli.

1998 - 1999 Interaction between the replicational initiator DnaA and the DNA polymerase components

1996 - 1999 Development of Anti-malarial Drug and it's Molecular Target

1997 - 1998 Molecular design of inhibitors for DNA replication in Escherichia coli

1997 - 1997 マウス個体レベルでの分子シャペロンのDNA超ら旋構造調節に関する分子

1997 - 1997 染色体の複製開始の頻度と同時性の制御装置

1996 - 1997 ストレス誘導性のDNAトポロジー変化のヒト細胞での解析

1996 - 1997 Changes of DNA supercoiling in Escherichia coli induced by stress

1996 - 1996 大腸菌DnaAタンパク質機能の制御装置の分子機構

1994 - 1996 Screening of inhibitors of DNA replication by using the oriC plasmid replication system of Escherichia coli

1994 - 1995 Biochemical and genetic study of the regulatory mechanism of the chromosomal DNA replication in Escherichia coli

1993 - 1995 Principle of Stress Response

1993 - 1994 Screaning of E.coli Genes That Participate in the Partitioning of F Plasmid DNA

1992 - 1993 A study of the topological change of DNA in Escherichia coli induced by heat shock.

1991 - 1992 Studies on the conformation and functions of ras-related low Mr GTP-binding proteins.

1991 - 1991 大学における研究設備の整備充実に関する調査研究

1990 - 1990 X線構造解析のためのDNA複製開始系蛋白質dnaAの結晶化

1990 - 1990 細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究

1989 - 1989 細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究

1988 - 1988 細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究

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Papers (35)：

Junhao Fu, Yosuke Nakata, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Molecular Editing Enhances Oxidation Resistance of Mena-quinone-Targeting Antibiotics Lysocin E and WAP-8294A2. Chemistry - A European Journal. 2023
Yosuke Nakata, Junhao Fu, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives. Chemistry (Weinheim an der Bergstrasse, Germany). 2023. e202301225
Atsushi Miyashita, Keiko Kataoka, Toshio Tsuchida, Akihiko Ano Ogasawara, Hiroto Nakajima, Megumu Takahashi, Kazuhisa Sekimizu. High molecular weight glucose homopolymer of broccoli (Brassica oleracea var. italica) stimulates both invertebrate and mammalian immune systems. Frontiers in Food Science and Technology. 2023. 3
浜本洋, Panthee Suresh, Paudel Atmika, 宮下惇嗣, 関水和久. 選抜ワークショップ5:抗菌性物質、薬剤耐性新規抗生物質ライソシンEは宿主と微生物の相互作用を利用して高い治療効果を発揮する. 日本細菌学雑誌. 2022. 77. 1. 57-57
Atsushi Miyashita, Shuhei Mitsutomi, Tohru Mizushima, Kazuhisa Sekimizu. Repurposing the PDMA-approved drugs in Japan using an insect model of staphylococcal infection. FEMS microbes. 2022. 3. xtac014

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MISC (157)：

関水和久, 三上雄大, YU Yidong, 李文淵, 宮下惇嗣, 石島早苗. カイコを用いた敗血症性サイトカインストーム機構モデルの構築. 日本生化学会大会(Web). 2023. 96th
宮下惇嗣, 斎藤優, 藤本ゆかり, 新家一男, 関水和久. Innate immunity to microbial pathogens. 日本細菌学雑誌(Web). 2023. 78. 1
関水和久, 宮下惇嗣, LI Wenyuan, 三上雄大, YU Yidong, 浜本洋. Construction of septic disseminated intravascular coagulation (DIC) model using the silkworm, Bombyx mori. 日本薬学会年会要旨集(Web). 2023. 143rd
Hiroshi Hamamoto, Atsushi Miyashita, Koushirou Kamura, Ryo Horie, Kazuhisa Sekimizu. Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret. Drug discoveries & therapeutics. 2022. 16. 6. 280-285
Atsushi Miyashita, Kazuhisa Sekimizu, Chikara Kaito. Surrounding gas composition affects the calling song development in the two-spotted cricket (Gryllus bimaculatus). Drug discoveries & therapeutics. 2022. 16. 5. 204-209

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Lectures and oral presentations (100)：

Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret.
(Drug discoveries & therapeutics 2022)
Surrounding gas composition affects the calling song development in the two-spotted cricket (Gryllus bimaculatus).
(Drug discoveries & therapeutics 2022)
Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220.
(Heliyon 2022)
Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs.
(Antimicrobial agents and chemotherapy 2022)
Transcriptome change of Staphylococcus aureus in infected mouse liver.
(Communications biology 2022)

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