Art

J-GLOBAL ID：202302225374509671   Reference number：23A1075332

Clinical translation of patient-derived tumour organoids- bottlenecks and strategies

患者由来腫瘍オルガノイドの臨床的翻訳-ボトルネックと戦略【JST・京大機械翻訳】

Author (23)： Alexandra Foo, Malia (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Mingliang You, (Hangzhou Cancer Institute, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou, China) ,  Mingliang You, (Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Leng Chan, Shing (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Leng Chan, Shing (Department of Surgery, National University Hospital, Singapore, Singapore) ,  Gautam Sethi, (NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Gautam Sethi, (Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  K. Bonney, Glenn (Department of Surgery, National University Hospital, Singapore, Singapore) ,  K. Bonney, Glenn (NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Wei-Peng Yong, (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Wei-Peng Yong, (Department of Haematology-Oncology, National University Hospital, National University Health System, Singapore, Singapore) ,  Kai-Hua Chow, Edward (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Kai-Hua Chow, Edward (NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Kai-Hua Chow, Edward (Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Shan Fong, Eliza Li (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Shan Fong, Eliza Li (Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore) ,  Lingzhi Wang, (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Lingzhi Wang, (NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Lingzhi Wang, (Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Boon-Cher Goh, (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore) ,  Boon-Cher Goh, (NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Boon-Cher Goh, (Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Boon-Cher Goh, (Department of Haematology-Oncology, National University Hospital, National University Health System, Singapore, Singapore)
Material： Biomarker Research (Web)
Volume： 10  Issue： 1  Page： 1-18  Publication year： 2022 
JST Material Number： U7304A  ISSN： 2050-7771  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Multiple three-dimensional (3D...

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Thesaurus term： optimization ,  *tumor ,  tumor cell ,  phenotype ,  utilization ,  image processing ,  artificial intelligence ,  multiplex ,  clinical trial ,  model ,  three dimension ,  screening(inspection) ,  workflow
Semi thesaurus term： *オルガノイド ,  循環腫瘍細胞 ,  創薬 ,  薬物スクリーニング ,  臨床応用 , 【Automatic Indexing@JST】

Author keywords (5)： Tumour ,  Organoid ,  Precision ,  Medicine ,  Three-Dimensional (3D)

JST classification (1)： Basic oncology in general  (GE02010R)

Reference (104)：

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• Cell; Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future; N McGranahan, C Swanton; 168; 4; 2017; 613-628; citation_id=CR2
• Mol Oncol; Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity; DV Catenacci; 9; 5; 2015; 967-996; citation_id=CR3
• Nat Cell Biol; Organoids as an in vitro model of human development and disease; A Fatehullah, SH Tan, N Barker; 18; 3; 2016; 246-254; citation_id=CR4
• Acta Biomater; Design of spherically structured 3D in vitro tumor models -Advances and prospects; LP Ferreira, VM Gaspar, JF Mano; 75; 2018; 11-34; citation_id=CR5

Terms in the title (6)： 患者 ,  腫瘍オルガノイド ,  臨床 ,  翻訳 ,  ボトルネック ,  戦略