Art

J-GLOBAL ID：202302225983563718   Reference number：23A0656042

Similar Piperacillin/Tazobactam Target Attainment in Obese versus Nonobese Patients despite Differences in Interstitial Tissue Fluid Pharmacokinetics

間質組織液薬物動態の違いにもかかわらず肥満対非肥満患者における類似ピペラシリン/タゾバクタム標的達成【JST・京大機械翻訳】

Author (19)： Busse David (Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 12169 Berlin, Germany) ,  Busse David (Graduate Research Training Program PharMetrX, 12169 Berlin, Germany) ,  Simon Philipp (Department of Anesthesiology, Intensive Care, University of Leipzig Medical Centre, 04103 Leipzig, Germany) ,  Simon Philipp (Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, 04103 Leipzig, Germany) ,  Petroff David (Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, 04103 Leipzig, Germany) ,  Petroff David (Clinical Trial Centre Leipzig, University of Leipzig, 04109 Leipzig, Germany) ,  Dorn Christoph (Institute of Pharmacy, University of Regensburg, 93053 Regensburg, Germany) ,  Schmitt Lisa (Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 12169 Berlin, Germany) ,  Schmitt Lisa (Graduate Research Training Program PharMetrX, 12169 Berlin, Germany) ,  Bindellini Davide (Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 12169 Berlin, Germany) ,  Bindellini Davide (Graduate Research Training Program PharMetrX, 12169 Berlin, Germany) ,  Kratzer Alexander (Hospital Pharmacy, University Hospital Regensburg, 93053 Regensburg, Germany) ,  Dietrich Arne (Department of Anesthesiology, Intensive Care, University of Leipzig Medical Centre, 04103 Leipzig, Germany) ,  Zeitlinger Markus (Department of Clinical Pharmacology, University Medical University of Vienna, 1090 Vienna, Austria) ,  Huisinga Wilhelm (Institute of Mathematics, University of Potsdam, 14469 Potsdam, Germany) ,  Michelet Robin (Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 12169 Berlin, Germany) ,  Wrigge Hermann (Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, 04103 Leipzig, Germany) ,  Wrigge Hermann (Department of Anesthesiology, Intensive Care and Emergency Medicine, Pain Therapy, Bergmannstrost Hospital Halle, 06112 Halle, Germany) ,  Kloft Charlotte (Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 12169 Berlin, Germany)
Material： Pharmaceutics (Web)
Volume： 13  Issue： 9  Page： 1380  Publication year： 2021 
JST Material Number： U7258A  ISSN： 1999-4923  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Precision dosing of piperacill...

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Thesaurus term： plasma(blood) ,  *interstitial tissue ,  drug distribution ,  dyeing ,  pharmacokinetics ,  kidney disease ,  *obesity ,  clinical trial ,  *patient ,  dose ,  minimal inhibitory concentration ,  subcutaneous fat ,  pharmacodynamics ,  carboxylic acid ,  aromatic compound ,  lactam ,  urea compound ,  sulfur heterocyclic compound ,  combination drug
Semi thesaurus term： 分布容積 , 【Automatic Indexing@JST】

Author keywords (3)： piperacillin/tazobactam ,  target-site ,  obesity

JST classification (5)： Clinical application of antibiotics acting on pathogenic organisms  (GX05030N) ,  Clinical biopharmacy  (GY01022L) ,  Clinical application of antibacterial drugs  (GW17030D) ,  Basic biopharmacy  (GY01021U) ,  Treatment for infectious diseases,parasitic diseases.  (GD01030D)

Substance index (2)： Piperacillin ,  piperacillin/Tazobactam

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• Löfgren, M.; Poromaa, I.S.; Stjerndahl, J.H.; Renström, B. Postoperative infections and antibiotic prophylaxis for hysterectomy in Sweden: A study by the Swedish National Register for Gynecologic Surgery. Acta Obstet. Gynecol. Scand. 2004, 83, 1202-1207.
• Olsen, M.A.; Mayfield, J.; Lauryssen, C.; Polish, L.B.; Jones, M.; Vest, J.; Fraser, V. Risk factors for surgical site infection in spinal surgery. J. Neurosurg. Spine 2003, 98, 149-155.

Terms in the title (9)： 間質組織 ,  薬物動態 ,  肥満 ,  非肥満 ,  患者 ,  類似 ,  ピペラシリン ,  タゾバクタム ,  標的