Art

J-GLOBAL ID：202302228899775218   Reference number：23A0656390

Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention

ヒストンデアセチラーゼの標的化:癌治療と化学予防の機会【JST・京大機械翻訳】

Author (7)： Ruzic Dusan (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia) ,  Djokovic Nemanja (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia) ,  Srdic-Rajic Tatjana (Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia) ,  Echeverria Cesar (Facultad de Medicina, Universidad de Atacama, Copayapu 485, Copiapo 1531772, Chile) ,  Nikolic Katarina (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia) ,  Santibanez Juan F. (Group for Molecular Oncology, Institute for Medical Research, National Institute of the Republic of Serbia, University of Belgrade, Dr. Subotica 4, POB 102, 11129 Belgrade, Serbia) ,  Santibanez Juan F. (Centro Integrativo de Biologia y Quimica Aplicada (CIBQA), Universidad Bernardo O’Higgins, Santiago 8370854, Chile)
Material： Pharmaceutics (Web)
Volume： 14  Issue： 1  Page： 209  Publication year： 2022 
JST Material Number： U7258A  ISSN： 1999-4923  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The dysregulation of gene expr...

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Thesaurus term： zinc ,  acetylation ,  *histone ,  chimera ,  clinical trial ,  cell cycle ,  malignant disease ,  *therapy ,  small molecule ,  gene expression ,  *targeting ,  cell differentiation ,  cell death ,  *histone deacetylase ,  epigenetics
Semi thesaurus term： *癌治療 , 【Automatic Indexing@JST】

Author keywords (9)： histone deacetylases ,  cancer ,  epigenetic ,  chemoprevention ,  HDAC inhibitors ,  dietary-derived inhibitors ,  bifunctional inhibitors ,  PROTAC ,  clinical trials

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Reference (283)：

• Feinberg, A.P.; Ohlsson, R.; Henikoff, S. The epigenetic progenitor origin of human cancer. Nat. Rev. Genet. 2006, 7, 21-33.
• Feinberg, A.P.; Vogelstein, B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983, 301, 89-92.
• Herman, J.G.; Baylin, S.B. Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 2003, 349, 2042-2054.
• Li, Z.; Lin, G.-L.; Yan, P.; Huang, J.; Wang, Y.-L. The expression of H3K9Ac, H3K14Ac, and H4K20TriMe in epithelial ovarian tumors and the clinical significance. Int. J. Gynecol. Cancer 2010, 20, 82-86.
• Fraga, M.F.; Ballestar, E.; Villar-Garea, A.; Boix-Chornet, M.; Espada, J.; Schotta, G.; Bonaldi, T.; Haydon, C.; Ropero, S.; Petrie, K.; et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 2005, 37, 391-400.

Terms in the title (5)： ヒストンデアセチラーゼ ,  標的化 ,  癌治療 ,  化学予防 ,  機会