Art

J-GLOBAL ID：202302232005339811   Reference number：23A2188789

The Role of SLC7A11 in Cancer: Friend or Foe?

癌におけるSLC7A11の役割:友人か敵か?【JST・京大機械翻訳】

Author (8)： Li Sijia (China Pharmaceutical University Nanjing Drum Tower Hospital, Nanjing 210000, China) ,  Li Sijia (Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou 215006, China) ,  Lu Zhenyao (Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China) ,  Sun Runbin (Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China) ,  Guo Suhan (Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China) ,  Gao Fangfang (Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China) ,  Cao Bei (Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China) ,  Aa Jiye (Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China)
Material： Cancers (Web)
Volume： 14  Issue： 13  Page： 3059  Publication year： 2022 
JST Material Number： U7153A  ISSN： 2072-6694  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： SLC7A11 controls the uptake of...

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Thesaurus term： *tumor ,  tumor cell ,  drug resistance ,  cell proliferation ,  cell physiology ,  pharmacology ,  gene expression ,  targeting ,  therapeutic planning ,  cell death ,  tumorigenesis ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  dicarboxylic acid ,  primary amine
Semi thesaurus term： 調節因子 ,  治療標的 ,  細胞代謝 ,  過剰発現 ,  腫瘍治療 , 【Automatic Indexing@JST】

Author keywords (6)： SLC7A11 ,  tumour ,  tumourigenesis ,  survival and proliferation ,  metastasis ,  therapeutic resistance

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Glutamic acid

Reference (159)：

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• Verrey, F.; Closs, E.I.; Wagner, C.A.; Palacin, M.; Endou, H.; Kanai, Y. CATs and HATs: The SLC7 family of amino acid transporters. Pflug. Arch. Eur. J. Physiol. 2004, 447, 532-542.
• Lim, J.C.; Donaldson, P.J. Focus on molecules: The cystine/glutamate exchanger (System xc-). Exp. Eye Res. 2011, 92, 162-163.
• Lewerenz, J.; Hewett, S.J.; Huang, Y.; Lambros, M.; Gout, P.W.; Kalivas, P.W.; Massie, A.; Smolders, I.; Methner, A.; Pergande, M.; et al. The cystine/glutamate antiporter system xc- in health and disease: From molecular mechanisms to novel therapeutic opportunities. Antioxid. Redox Signal. 2013, 18, 522-555.
• Ishii, T.; Mann, G.E. Redox status in mammalian cells and stem cells during culture in vitro: Critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance. Redox Biol. 2014, 2, 786-794.

Terms in the title (3)： 癌 ,  役割 ,  友人