Art

J-GLOBAL ID：202302234959479944   Reference number：23A1723821

Therapeutic implications of current Janus kinase inhibitors as anti-COVID agents: A review

抗COVID薬としての現在のJanusキナーゼ阻害剤の治療的意味:レビュー【JST・京大機械翻訳】

Author (13)： Jain Nem Kumar (1School of Pharmacy, ITM University, Gwalior, Madhya Pradesh, India) ,  Jain Nem Kumar (2School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India) ,  Tailang Mukul (2School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India) ,  Jain Hemant Kumar (3Department of General Medicine, Government Medical College, Datia, Madhya Pradesh, India) ,  Chandrasekaran Balakumar (4Faculty of Pharmacy, Philadelphia University, Amman, Jordan) ,  Sahoo Biswa Mohan (5Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India) ,  Subramanian Anandhalakshmi (6Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Saudi Arabia) ,  Thangavel Neelaveni (7Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, Saudi Arabia) ,  Aldahish Afaf (8Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia) ,  Chidambaram Kumarappan (8Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia) ,  Alagusundaram M. (1School of Pharmacy, ITM University, Gwalior, Madhya Pradesh, India) ,  Kumar Santosh (9School of Sciences, ITM University, Gwalior, Madhya Pradesh, India) ,  Selvam Palani (10School of Medicine, College of Medicine and Health Sciences, Jijiga University, Jijiga, Ethiopia)
Material： Frontiers in Pharmacology (Web)
Volume： 14  Page： 1135145  Publication year： 2023 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Severe cases of COVID-19 are c...

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Thesaurus term： allergic reaction ,  inflammation ,  *immunity ,  immunotherapeutic drug ,  clinical trial ,  combination therapy ,  small molecule ,  targeting ,  cellular signal transduction ,  multiple organ failure ,  interleukin 6 ,  pathogenesis ,  *non-receptor tyrosine kinase ,  STAT transcription factor ,  natural immunity
Semi thesaurus term： *Janusキナーゼ ,  COVID-19 , 【Automatic Indexing@JST】

Author keywords (8)： Janus kinase ,  JAKs ,  JAK-STAT pathway ,  JAKi ,  Jakinibs ,  kinase inhibitors ,  COVID-19 ,  SARS-CoV-2

JST classification (3)： Immunological reaction in general  (ED03010T) ,  Cell physiology in general  (EF02010S) ,  Immunologic diseases,allergic diseases in general.  (GD04010C)

Reference (176)：

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• AgrawalM., BrennerE. J., ZhangX., ModestoI., WoolcottJ., UngaroR. C., et al (2021). Characteristics and outcomes of IBD patients with COVID-19 on tofacitinib therapy in the SECURE-IBD registry. Inflamm. Bowel Dis. 27, 585-589. doi: 10.1093/ibd/izaa303
• Akbarzadeh-KhiaviM., TorabiM., RahbarniaL., SafaryA. (2022). Baricitinib combination therapy: A narrative review of repurposed janus kinase inhibitor against severe SARS-CoV-2 infection. Infection 50, 295-308. doi: 10.1007/s15010-021-01730-6
• AkkocN., KhanM. A. (2021). JAK inhibitors for axial spondyloarthritis: What does the future hold? Curr. Rheumatol. Rep. 23, 34. doi: 10.1007/s11926-021-01001-1
• Al-AniB., ShamsEldeenA. M., KamarS. S., HaidaraM. A., Al-HashemF., AlshahraniM. Y., et al (2022). Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe Covid-19 pathology. Clin. Exp. Pharmacol. Physiol. 49, 483-491. doi: 10.1111/1440-1681.13620

Terms in the title (5)： Janusキナーゼ ,  阻害剤 ,  治療 ,  意味 ,  レビュー