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J-GLOBAL ID：202302239443995018   Reference number：23A1334444

A Novel and Practical Synthesis of 5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile, a Key Intermediate of Vericiguat

ベルシグアトの重要な中間体,5-フルオロ-1-(2-フルオロベンジル)-1H-ピラゾロ[3,4-b]ピリジン-3-カルボニトリルの新規で実用的な合成【JST・京大機械翻訳】

Author (6)： Bi Siju (State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, P. R. China) ,  Diao Wenshuang (State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, P. R. China) ,  Tian Ting (State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, P. R. China) ,  Zhou Ting (State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, P. R. China) ,  Lin Kuaile (State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, P. R. China) ,  Zhou Weicheng (State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, P. R. China)
Material： Organic Process Research & Development  (Org Process Res Dev)
Volume： 27  Issue： 4  Page： 755-762  Publication year： 2023 
JST Material Number： W1013A  ISSN： 1083-6160  CODEN： OPRDFK  Document type： Article
Article type： 文献レビュー  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： 5-Fluoro-1-(2-fluorobenzyl)-1H...

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Thesaurus term： NMR ,  mass spectrometry ,  single crystal ,  palladium catalyst ,  cyanation ,  benzylation ,  hydrazinolysis ,  *intermediate ,  X-ray crystallography

Author keywords (5)： vericiguat ,  hydrazinolysis ,  intramolecular substitution ,  benzylation ,  Pd-catalyzed cyanation

JST classification (5)： Addition reaction,elimination reaction  (CF02030M) ,  Platinum family element complexes  (CE01100E) ,  Synthesis of drugs  (GV01030F) ,  Aliphatic alcohols  (CF03090H) ,  Nobel metal catalysts  (CB06122I)

Terms in the title (2)： 中間体 ,  ピリジン-3-カルボニトリル