Art

J-GLOBAL ID：202302241001641286   Reference number：23A0585360

Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules

改変キメラMHC-I分子によるT細胞受容体認識からのペプチド結合の分離【JST・京大機械翻訳】

Author (14)： Papadaki Georgia F. (1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States) ,  Papadaki Georgia F. (2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States) ,  Ani Omar (1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States) ,  Florio Tyler J. (1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States) ,  Florio Tyler J. (2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States) ,  Young Michael C. (1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States) ,  Young Michael C. (2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States) ,  Danon Julia N. (1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States) ,  Danon Julia N. (2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States) ,  Sun Yi (1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States) ,  Sun Yi (2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States) ,  Dersh Devin (3Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States) ,  Sgourakis Nikolaos G. (1Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States) ,  Sgourakis Nikolaos G. (2Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States)
Material： Frontiers in Immunology (Web)
Volume： 14  Page： 1116906  Publication year： 2023 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Major Histocompatibility Compl...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=23A0585360&from=J-GLOBAL&jstjournalNo=U7074A") }}

Thesaurus term： interaction ,  steric conformation ,  *peptide ,  antigen ,  *chimera ,  complex(substance) ,  *peptide bond ,  allele ,  human leucocyte antigen ,  tetramer ,  screening(inspection) ,  heavy chain ,  in vitro experiment ,  *T cell receptor
Semi thesaurus term： 残基 , 【Automatic Indexing@JST】

Author keywords (6)： major histocompatibility complex (MHC) ,  antigen presentation ,  chimeric molecules ,  T cell receptors ,  structural immunology ,  cancer immunotherapy

JST classification (2)： Immunological reaction in general  (ED03010T) ,  Biochemistry of antigens,antibodies,complements  (ED04020L)

Reference (72)：

• Zimmer J, Andrès E, Donato L, Hanau D, Hentges F, de la Salle H. Clinical and immunological aspects of HLA class I deficiency. QJM: Int J Med (2005) 98:719-27. doi: doi: 10.1093/qjmed/hci112
• Blum JS, Wearsch PA, Cresswell P. Pathways of antigen processing. Annu Rev Immunol (2013) 31:443-73. doi: doi: 10.1146/annurev-immunol-032712-095910
• Riedhammer C, Weissert R. Antigen presentation, autoantigens, and immune regulation in multiple sclerosis and other autoimmune diseases. Front Immunol (2015) 6:322. doi: doi: 10.3389/fimmu.2015.00322
• Koutsakos M, Illing PT, Nguyen THO, Mifsud NA, Crawford JC, Rizzetto S, et al. Human CD8+ T cell cross-reactivity across influenza a, b and c viruses. Nat Immunol (2019) 20:613-25. doi: doi: 10.1038/s41590-019-0320-6
• Dhatchinamoorthy K, Colbert JD, Rock KL. Cancer immune evasion through loss of MHC class I antigen presentation. Front Immunol (2021) 12:636568. doi: doi: 10.3389/fimmu.2021.636568

Terms in the title (6)： 改変 ,  キメラ ,  MHC ,  分子 ,  T細胞受容体 ,  ペプチド結合