Art

J-GLOBAL ID：202302242398512095   Reference number：23A0567791

A diet enriched in omega-3 PUFA and inulin prevents type 1 diabetes by restoring gut barrier integrity and immune homeostasis in NOD mice

オメガ-3PUFAとイヌリンに豊富な食事はNODマウスにおける腸バリア完全性と免疫恒常性の回復により1型糖尿病を予防する【JST・京大機械翻訳】

Author (14)： Lo Conte Marta (1Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Lo Conte Marta (2Universita Vita-Salute San Raffaele, Milan, Italy) ,  Antonini Cencicchio Martina (1Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Antonini Cencicchio Martina (2Universita Vita-Salute San Raffaele, Milan, Italy) ,  Ulaszewska Marynka (3Proteomics and Metabolomics Facility (ProMeFa), IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Nobili Angelica (1Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Cosorich Ilaria (1Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Ferrarese Roberto (4Laboratory of Medical Microbiology and Virology, IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Massimino Luca (5Experimental Gastroenterology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Andolfo Annapaola (3Proteomics and Metabolomics Facility (ProMeFa), IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Ungaro Federica (5Experimental Gastroenterology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Mancini Nicasio (4Laboratory of Medical Microbiology and Virology, IRCCS San Raffaele Scientific Institute, Milan, Italy) ,  Mancini Nicasio (6Laboratory of Medical Microbiology and Virology, Universita “Vita-Salute” San Raffaele, Milan, Italy) ,  Falcone Marika (1Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Material： Frontiers in Immunology (Web)
Volume： 13  Page： 1089987  Publication year： 2022 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Introduction: The integrity of...

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Thesaurus term： bacterium ,  mRNA ,  anti-inflammatory action ,  intestinal mucosa ,  mucin ,  *mouse(animal) ,  lymph node ,  autoimmunity ,  homeostasis ,  microflora ,  mucus ,  *type 1 diabetes mellitus ,  interleukin 1 ,  pathogenesis ,  Th1 cell

Author keywords (6)： anti-inflammatory diet (AID) ,  Type 1 diabetes ,  gut barrier integrity ,  mucus layer ,  gut microbiota ,  regulatory T cells

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Immunological reaction in general  (ED03010T) ,  Immunologic diseases,allergic diseases in general.  (GD04010C)

Reference (62)：

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• Kostic AD, Gevers D, Siljander H, Vatanen T, Hyotylainen T, Hamalainen AM, et al. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe (2015) 17(2):260-73. doi: doi: 10.1016/j.chom.2015.01.001
• Siljander H, Honkanen J, Knip M. Microbiome and type 1 diabetes. EBioMedicine (2019) 46:512-21. doi: doi: 10.1016/j.ebiom.2019.06.031
• Bosi E, Molteni L, Radaelli MG, Folini L, Fermo I, Bazzigaluppi E, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia (2006) 49(12):2824-7. doi: doi: 10.1007/s00125-006-0465-3

Terms in the title (11)： オメガ ,  イヌリン ,  食事 ,  NODマウス ,  腸バリア ,  完全性 ,  免疫 ,  恒常性 ,  回復 ,  1型糖尿病 ,  予防