Art

J-GLOBAL ID：202302248757645720   Reference number：23A0799198

Synthesis and Evaluation of 2-Amine-4-oxyphosaniline Pyrimidine Derivatives as EGFR L858R/T790M/C797S Mutant Inhibitors

EGFRのL858R/T790M/C797S変異体の阻害剤としての2-アミン-4-オキシホスアニリンピリミジン誘導体の合成及び評価

Author (7)： Zhang Mingguang (Jiangsu Vocational College of Medicine) ,  Yang Yang (Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd.) ,  Wang Yunyun (School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University) ,  Wang Jia (Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd.) ,  Wu Hongyan (Jiangsu Vocational College of Medicine) ,  Zhu Yongqiang (Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd.) ,  Zhu Yongqiang (College of Life Science, Nanjing Normal University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 71  Issue： 2  Page： 140-147(J-STAGE)  Publication year： 2023 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...
Semi thesaurus term： *EGFR inhibitor ,...

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Author keywords (10)： L858R/T790M/C797S mutant ,  2-amine-4-oxyphosaniline pyrimidine derivative ,  epidermal growth factor receptor (EGFR) inhibitor ,  synthesis ,  biological activity evaluation ,  L858R/T790M/C797S mutant ,  2-amine-4-oxyphosaniline pyrimidine derivative ,  epidermal growth factor receptor (EGFR) inhibitor ,  synthesis ,  biological activity evaluation

JST classification (2)： Synthesis of drugs  (GV01030F) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (2)： 5-ブロモ-N4-[2-(ジメチルホスホリル)フェニル]-N2-{2-メトキシ-5-メチル-4-[4-(モルホリン-4-イル)ピペリジン-1-イル]フェニル}ピリミジン-2,4-ジアミン ,  AZD-9291

Reference (32)：

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Terms in the title (6)： EGFR ,  変異体 ,  阻害剤 ,  アミン ,  誘導体 ,  評価