Art

J-GLOBAL ID：202302254585753646   Reference number：23A0569691

Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19

症例報告: COVID-19に入院した2つの免疫不全患者におけるサルベージ治療選択肢としてのソトロビマブ,レムデシビルおよびニルマトレルビル/リトナビル併用【JST・京大機械翻訳】

Author (25)： Baldi Federico (Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy) ,  Baldi Federico (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Dentone Chiara (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Mikulska Malgorzata (Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy) ,  Mikulska Malgorzata (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Fenoglio Daniela (Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy) ,  Fenoglio Daniela (Biotherapy Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Mirabella Michele (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Magne Federica (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Portunato Federica (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Altosole Tiziana (Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy) ,  Sepulcri Chiara (Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy) ,  Sepulcri Chiara (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Giacobbe Daniele Roberto (Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy) ,  Giacobbe Daniele Roberto (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Uras Chiara (Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy) ,  Scavone Graziana (Biotherapy Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Taramasso Lucia (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Orsi Andrea (Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy) ,  Orsi Andrea (Hygiene Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Cittadini Giuseppe (General Radiology, Polyclinic San Martino Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy) ,  Filaci Gilberto (Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy) ,  Filaci Gilberto (Biotherapy Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy) ,  Bassetti Matteo (Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy) ,  Bassetti Matteo (Infectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, Italy)
Material： Frontiers in Medicine (Web)
Volume： 9  Page： 1062450  Publication year： 2022 
JST Material Number： U7079A  ISSN： 2296-858X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： COVID-19 in immunocompromised ...

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Thesaurus term： interaction ,  RNA ,  antiviral drug ,  biological preparation ,  salvage ,  viral replication ,  combination therapy ,  monoclonal antibody ,  *immunologic deficiency syndrome ,  vasculitis ,  case report ,  non-Hodgkin's lymphoma ,  molecular targeting drug
Semi thesaurus term： 疾患進行 ,  リツキシマブ ,  *免疫不全患者 ,  *COVID-19 , 【Automatic Indexing@JST】

Author keywords (7)： salvage therapy ,  COVID-19 ,  immunocompromised ,  monoclonal antibodies ,  sotrovimab ,  nirmatrelvir/ritonavir ,  remdesivir

JST classification (3)： Infectious diseases,parasitics diseases in general.  (GD01010H) ,  Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M) ,  Clinical application of immunotherapeutic agents and blood preparations  (GW22020O)

Substance index (1)： Remdesivir

Reference (46)：

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• Weinreich DM, Sivapalasingam S, Norton T, Ali S, Gao H, Bhore R, et al REGEN-COV antibody combination and outcomes in outpatients with COVID-19. N Engl J Med. (2021) 385:e81. doi: 10.1056/NEJMoa2108163
• Group Recovery Collaborative. Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. (2022) 399:665-76. doi: 10.1016/S0140-6736(22)00163-5
• Dougan M, Nirula A, Azizad M, Mocherla B, Gottlieb RL, Chen P, et al Bamlanivimab plus etesevimab in mild or moderate COVID-19. N Engl J Med. (2021) 385:1382-92. doi: 10.1056/NEJMoa2102685
• Gupta A, Gonzalez-Rojas Y, Juarez E, Casal MC, Moya J, Falci DR, et al Early treatment for COVID-19 with SARS-CoV-2 neutralizing antibody sotrovimab. N Engl J Med. (2021) 385:1941-50. doi: 10.1056/NEJMoa2107934

Terms in the title (8)： 症例報告 ,  入院 ,  免疫不全患者 ,  サルベージ ,  治療選択肢 ,  レムデシビル ,  リトナビル ,  併用