Art

J-GLOBAL ID：202302259203663504   Reference number：23A1724637

Fecal microbiota transplantation in Parkinson’s disease-A randomized repeat-dose, placebo-controlled clinical pilot study

パーキンソン病における糞便微生物叢移植-無作為化反復用量,プラセボ対照臨床パイロット研究【JST・京大機械翻訳】

Author (15)： DuPont Herbert L. (Microbiome Research Center, Kelsey Research Foundation, Houston, TX, United States) ,  DuPont Herbert L. (Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States) ,  DuPont Herbert L. (Department of Internal Medicine, University of Texas McGovern Medical School, Houston, TX, United States) ,  DuPont Herbert L. (Medical Services and Specialties, Kelsey Seybold Clinic, Houston, TX, United States) ,  Suescun Jessika (Department of Neurology, University of Texas McGovern Medical School, Houston, TX, United States) ,  Jiang Zhi-Dong (Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States) ,  Brown Eric L. (Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States) ,  Essigmann Heather T. (Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States) ,  Alexander Ashley S. (Microbiome Research Center, Kelsey Research Foundation, Houston, TX, United States) ,  DuPont Andrew W. (Department of Internal Medicine, University of Texas McGovern Medical School, Houston, TX, United States) ,  Iqbal Tehseen (Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States) ,  Utay Netanya S. (Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States) ,  Newmark Michael (Microbiome Research Center, Kelsey Research Foundation, Houston, TX, United States) ,  Newmark Michael (Medical Services and Specialties, Kelsey Seybold Clinic, Houston, TX, United States) ,  Schiess Mya C. (Department of Neurology, University of Texas McGovern Medical School, Houston, TX, United States)
Material： Frontiers in Neurology (Web)
Volume： 14  Page： 1104759  Publication year： 2023 
JST Material Number： U7085A  ISSN： 1664-2295  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Background and purpose: The in...

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Thesaurus term： bacterium ,  *placebo ,  oral administration ,  intestine ,  *feces ,  constipation ,  double blind test ,  *microflora ,  symptom ,  *transplantation ,  *Parkinson's disease ,  pathogenesis
Semi thesaurus term： プロテオバクテリア ,  被験者 ,  Firmicutes ,  非運動症状 , 【Automatic Indexing@JST】

Author keywords (5)： Parkinson’s disease ,  fecal microbiota transplantation ,  microbiome ,  dysbiosis ,  constipation

JST classification (1)： Treatment for digestive system diseases in general  (GH05010V)

Reference (68)：

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• Hill-Burns EM, Debelius JW, Morton JT, Wissemann WT, Lewis MR, Wallen ZD, et al. Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome. Mov Disord. (2017) 32:739-49. doi: 10.1002/mds.26942
• Sun MF, Zhu YL, Zhou ZL, Jia XB, Xu YD, Yang Q, et al. Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: gut microbiota, glial reaction and TLR4/TNF-alpha signaling pathway. Brain Behav Immun. (2018) 70:48-60. doi: 10.1016/j.bbi.2018.02.005

Terms in the title (11)： パーキンソン病 ,  糞便 ,  微生物叢 ,  移植 ,  反復 ,  用量 ,  プラセボ ,  対照 ,  臨床 ,  パイロット ,  研究