Art

J-GLOBAL ID：202302260752723792   Reference number：23A1068303

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

マンモグラフィー密度表現型のゲノムワイドおよびトランスクリプトームワイド関連研究は新規遺伝子座を明らかにする【JST・京大機械翻訳】

Author (77)： Hongjie Chen, (Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA) ,  Shaoqi Fan, (Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA) ,  Jennifer Stone, (School of Population and Global Health, University of Western Australia, Crawley, Australia) ,  J. Thompson, Deborah (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ,  Julie Douglas, (Department of Human Genetics, University of Michigan Medical School, Ann Arbor, USA) ,  Julie Douglas, (Department of Mathematics and Statistics, Skidmore College, Saratoga Springs, USA) ,  Shuai Li, (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ,  Shuai Li, (Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia) ,  Shuai Li, (Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia) ,  Christopher Scott, (Department of Health Sciences Research, Mayo Clinic, Rochester, USA) ,  K. Bolla, Manjeet (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ,  Qin Wang, (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ,  Joe Dennis, (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ,  Kyriaki Michailidou, (Biostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus) ,  Kyriaki Michailidou, (Cyprus School of Molecular Medicine, Nicosia, Cyprus) ,  Christopher Li, (Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA) ,  Christopher Li, (Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA) ,  Ulrike Peters, (Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA) ,  Ulrike Peters, (Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA) ,  L. Hopper, John (Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia) ,  C. Southey, Melissa (Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia) ,  Tu Nguyen-Dumont, (Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia) ,  L. Nguyen, Tuong (Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia) ,  A. Fasching, Peter (Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany) ,  Annika Behrens, (Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany) ,  Gemma Cadby, (School of Population and Global Health, University of Western Australia, Crawley, Australia) ,  A. Murphy, Rachel (Cancer Control Research, BC Cancer and School of Population and Public Health, University of British Columbia, Vancouver, Canada) ,  Kristan Aronson, (Public Health Sciences, Queen’s University, Kingston, Canada) ,  Anthony Howell, (Division of Cancer Sciences, University of Manchester, Manchester, UK) ,  Susan Astley, (Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK) ,  Fergus Couch, (Department of Health Sciences Research, Mayo Clinic, Rochester, USA) ,  Janet Olson, (Department of Health Sciences Research, Mayo Clinic, Rochester, USA) ,  L. Milne, Roger (Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia) ,  L. Milne, Roger (Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia) ,  L. Milne, Roger (Cancer Epidemiology Division, Melbourne, Australia) ,  G. Giles, Graham (Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia) ,  G. Giles, Graham (Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK) ,  G. Giles, Graham (Cancer Epidemiology Division, Melbourne, Australia) ,  A. Haiman, Christopher (Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA) ,  Gertraud Maskarinec, (Epidemiology Program, University of Hawaii Cancer Center, Honolulu, USA) ,  Stacey Winham, (Department of Health Sciences Research, Mayo Clinic, Rochester, USA) ,  M. John, Esther (Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, USA) ,  M. John, Esther (Department of Medicine (Oncology), Stanford University School of Medicine, Stanford, USA) ,  M. John, Esther (Stanford Cancer Institute, Stanford University School of Medicine, Stanford, USA) ,  Allison Kurian, (Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, USA) ,  Allison Kurian, (Department of Medicine (Oncology), Stanford University School of Medicine, Stanford, USA) ,  Allison Kurian, (Stanford Cancer Institute, Stanford University School of Medicine, Stanford, USA) ,  Heather Eliassen, (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA) ,  Heather Eliassen, (Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA) ,  Irene Andrulis, (Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada) ,  Irene Andrulis, (Department of Molecular Genetics, University of Toronto, Toronto, Canada) ,  Gareth Evans, D. (Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK) ,  Gareth Evans, D. (Genomic Medicine, St Mary’s Hospital, Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK) ,  Gareth Evans, D. (NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK) ,  G. Newman, William (Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK) ,  Per Hall, (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden) ,  Kamila Czene, (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden) ,  Anthony Swerdlow, (Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK) ,  Michael Jones, (Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK) ,  Marina Pollan, (Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain) ,  Pablo Fernandez-Navarro, (Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain) ,  S. McConnell, Daniel (Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA) ,  N. Kristensen, Vessela (Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway) ,  H. Rothstein, Joseph (Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA) ,  H. Rothstein, Joseph (Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Pei Wang, (Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA) ,  A. Habel, Laurel (Division of Research, Kaiser Permanente Northern California, Oakland, USA) ,  Weiva Sieh, (Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Weiva Sieh, (Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA) ,  M. Dunning, Alison (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ,  P. Pharoah, Paul D. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ,  F. Easton, Douglas (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ,  L. Gierach, Gretchen (Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA) ,  M. Tamimi, Rulla (Division of Epidemiology, Population Health Science, Weill Cornell Medicine, New York, USA) ,  M. Vachon, Celine (Department of Health Sciences Research, Mayo Clinic, Rochester, USA) ,  Sara Lindstrom, (Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA) ,  Sara Lindstrom, (Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA)
Material： Breast Cancer Research (Web)
Volume： 24  Issue： 1  Page： 1-15  Publication year： 2022 
JST Material Number： U7313A  ISSN： 1465-542X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Mammographic density (MD) phen...

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Thesaurus term： twin ,  *heredity ,  *gene ,  *phenotype ,  *genome ,  obesity ,  *gene locus ,  breast tumor ,  mammography ,  Genome-Wide Association Study
Semi thesaurus term： コンソーシアム ,  遺伝的変異 ,  遺伝的背景 ,  乳癌のリスク ,  *マンモグラフィー密度 , 【Automatic Indexing@JST】

Author keywords (4)： Mammographic density ,  Breast cancer ,  Genome-wide association study (GWAS) ,  Transcriptome-wide association study (TWAS)

JST classification (1)： Genetic variation  (EC01030Y)

Reference (47)：

• Breast Cancer Res; Mammographic density and breast cancer risk: current understanding and future prospects; NF Boyd, LJ Martin, MJ Yaffe, S Minkin; 13; 6; 2011; 223; 10.1186/bcr2942; citation_id=CR1
• Cancer Epidemiol Biomark Prev; Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis; VA McCormack, SI Santos; 15; 6; 2006; 1159-1169; 10.1158/1055-9965.EPI-06-0034; citation_id=CR2
• J Natl Cancer Inst; Mammographic density phenotypes and risk of breast cancer: a meta-analysis; A Pettersson, RE Graff, G Ursin, ID Santos Silva, V McCormack, L Baglietto, C Vachon, MF Bakker, GG Giles, KS Chia; 106; 5; 2014; dju078; 10.1093/jnci/dju078; citation_id=CR3
• Cancer Epidemiol Biomark Prev; Methodological challenges and updated findings from a meta-analysis of the association between mammographic density and breast cancer; D Bond-Smith, J Stone; 28; 1; 2019; 22-31; 10.1158/1055-9965.EPI-17-1175; citation_id=CR4
• CA Cancer J Clin; Cancer statistics, 2018; RL Siegel, KD Miller, A Jemal; 68; 1; 2018; 7-30; 10.3322/caac.21442; citation_id=CR5

Terms in the title (5)： マンモグラフィー密度 ,  表現型 ,  ゲノム ,  研究 ,  遺伝子座