Art

J-GLOBAL ID：202302291196969931   Reference number：23A1725110

Understanding the dosing-time-dependent antihypertensive effect of valsartan and aspirin through mathematical modeling

数学モデリングによるバルサルタンとアスピリンの投与時間依存性抗高血圧効果の理解【JST・京大機械翻訳】

Author (2)： Cortes-Rios Javiera (Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile) ,  Rodriguez-Fernandez Maria (Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile)
Material： Frontiers in Endocrinology (Web)
Volume： 14  Page： 1110459  Publication year： 2023 
JST Material Number： U7068A  ISSN： 1664-2392  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Chronopharmacology of arterial...

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Thesaurus term： optimization ,  *time ,  tantalum ,  *blood pressure ,  hypotensive drug ,  hypotensive action ,  heartbeat ,  pharmacological action ,  vascular resistance ,  pharmacokinetics ,  diurnal rhythm ,  pharmacology ,  *dosing period ,  fatty acid ,  aromatic carboxylic acid ,  phenolic compound ,  carboxylate(ester) ,  hydroxy acid ,  aliphatic amine ,  nitrogen heterocyclic compound ,  aromatic compound ,  aliphatic carboxylic acid ,  angiotensin antagonist
Semi thesaurus term： 被験者 ,  *投与時間 ,  抗血栓作用 , 【Automatic Indexing@JST】

Author keywords (7)： chronopharmacology ,  hypertension ,  mathematical modeling ,  blood pressure ,  circadian rhythm ,  valsartan ,  aspirin

JST classification (2)： Clinical application of vasoactive drugs and hypotensive drugs  (GW07050U) ,  Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M)

Substance index (2)： Aspirin ,  Valsartan

Reference (42)：

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• Hermida RC, Crespo JJ, Domínguez-Sardi M, Otero A, Moyá A, Ríos MT, et al. Bedtime hypertension treatment improves cardiovascular risk reduction: the hygia chronotherapy trial. Eur Heart J (2019) 41: 4565-76. doi: doi: 10.1093/eurheartj/ehz754
• Bowles NP, Thosar SS, Herzig MX, Shea SA. Chronotherapy for hypertension. Curr Hypertens Rep (2018) 20:97. doi: doi: 10.1007/S11906-018-0897-4
• Hermida RC, Hermida-Ayala RG, Smolensky MH, Mojón A, Fernández JR. Ingestion-time differences in the pharmacodynamics of hypertension medications: Systematic review of human chronopharmacology trials. Adv Drug Delivery Rev (2021) 170:200-13. doi: doi: 10.1016/J.ADDR.2021.01.013
• Hermida RC, Mojón A, Hermida-Ayala RG, Smolensky MH, Fernández JR. Extent of asleep blood pressure reduction by hypertension medications is ingestion-time dependent: Systematic review and meta-analysis of published human trials. Sleep Med Rev (2021) 59: 101454. doi: doi: 10.1016/J.SMRV.2021.101454

Terms in the title (7)： 数学モデリング ,  バルサルタン ,  アスピリン ,  投与 ,  時間依存性 ,  高血圧 ,  理解