Rchr

J-GLOBAL ID：202401004401212583 Update date: Apr. 25, 2025

Fujiko Tsukahara

ツカハラフジコ | Fujiko Tsukahara

Research theme for competitive and other funds (16)：

2009 - 2014 Endogenous TLR4 ligands in tumor metastasis.
2011 - 2014 エキソゾーム熱ショック蛋白質のToll様受容体を介する慢性骨髄性白血病発癌制御
2009 - 2013 内因性リガンドによって誘導される「自然炎症」の分子基盤とその破綻
2007 - 2008 分子シャペロンによる発癌原因分子チロシンキナーゼのキナーゼ領域依存性分解制御
2004 - 2006 分子シャペロンによる慢性骨髄性白血病原因遺伝子産物(BCR/ABL)の分解制御

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Papers (47)：

Tomita Takeshi, Ieguchi Katsuaki, Deguchi Atsuko, Takita Morichika, Tsukahara Fujiko, Hiratsuka Sachie, Maru Yoshiro. Lung Tumor Cell Recruitment Assay. Journal of visualized experiments : JoVE. 2019. 144. e53172
TAKITA Morichika†, TSUKAHARA Fujiko†, MISHIMA Taishi, IEGUCHI Katsuaki, YAMADA Masayuki, HONDA Hiroaki, MARU Yoshiro*. Paradoxical counteraction by imatinib against cell death in myeloid progenitor 32D cells expressing p210BCR-ABL. Oncotarget. 2018. 9. 60. 31682-31696
Tomita Takeshi†*, Ieguchi Katsuaki, Takita Morichika, Tsukahara Fujiko, Yamada Masayuki, Egly Jean-Marc, Maru Yoshiro*. C1D is not directly involved in the repair of UV-damaged DNA but protects cells from oxidative stress by regulating gene expressions in human cell lines. Journal of biochemistry. 2018. 164. 6. 415-426
Tsukahara Fujiko, Maru Yoshiro. Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy. Genes to Cells. 2018. 23. 1. 22-34
Maru Yoshiro, Tomita Takeshi*, Deguchi Atsuko, Ieguchi Katsuaki, Takita Morichika, Tsukahara Fujiko, Takemura Kazuhiro, Kitao Akio, Gusovsky Fabian. Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example. Endocrine, metabolic & immune disorders drug targets. 2015. 15. 2. 83-87

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MISC (9)：

Fujiko Tsukahara. Discovery of BCR-ABL chimeric gene, development of TKI for CML treatment, and overcoming drug resistance. SEITAI NO KAGAKU. 2023. 74. 4. 322-326
Tsukahara Fujiko, Maru Yoshiro. Secondary Publication: COVID-19 Pandemic: Drug Development and Treatment. Tokyo Women's Medical University Journal. 2021. Advance Publication. 1-10
COVID-19 Pandemic Drug Development and Drug Treatment. 2021. 91. 1. 19-28
Inflammatory Disease (6) Inflammation and Cancer. 2020. 90. 6. 119-125
Fujiko Tsukahara†, Yoshiro Maru. Malignant Tumor (4) Molecular Targeted Drugs. 2018. 88. 6. 129-137

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Books (5)：

抗腫瘍薬「エース薬理学」
南山堂 2020 ISBN:9784525140717
Imatinib: Basic Results,Chemotherapy for Leukemia Novel Drugs and Treatment
Springer 2017 ISBN:9789811033308
Induction of cationic amino acid transporter-2 mRNA by tumor necrosis factor-α is associated with nitric oxide production in human umbilical vein endothelial cells,The Biology of Nitric Oxide Part 6
PORTLAND PRESS 1998
Effect of tumor necrosis factor on the lipoprotein lipase gene expression in brown adipocytes differentiated in culture. Thermal Balance in Health and Disease,Advances in Pharmacological Sciences 1st ed
Springer Basel 1994 ISBN:9783034874311
エクソントラッピング法「ゲノムのマッピングとシークエンス解析法バイオマニュアルシリーズ6」
羊土社 1994

Lectures and oral presentations (25)：

ミクログリアにおける家族性ALS変異SOD1蛋白分解機構の解明
(第62回日本神経病理学会総会学術研究会 2021)
新しい臨床研究法
(第48回日本腎臓学会東部学術大会 2018)
Selective autophagy eliminates ALS-related mutant SOD1 protein in cultured microglia
(19th International Congress of Neuropathology 2018)
ミクログリアにおけるALS関連変異SOD1蛋白の除去機構の解明
(第12回臨床ストレス応答学会大会 2017)
Mechanism of ALS-related mutant SOD protein degradation in microglia
(2017)

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Professional career (1)：

医学博士 (東京女子医科大学)

Work history (9)：

2023/04 - 2025/03 東京女子医科大学研究推進センターセンター長特任教授
2020/04 - 2025/03 早稲田大学先進理工研究科客員教授
2020/04 - 2023/03 東京女子医科大学薬理学講座特任教授
2019/06 - 2020/03 東京女子医科大学薬理学教室准教授
2018/02 - 2020/03 東京女子医科大学特命担当教授

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Committee career (1)：

日本薬理学会評議員

Awards (2)：

2011/11 - 公益信託日本白血病基金一般研究賞
1996/02 - 山川寿子研究奨励賞

Association Membership(s) (5)：

日本薬理学会 , 日本臨床試験学会 , 日本臨床薬理学会 , 日本癌学会 , レギュラトリーサイエンス学会

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