Yamaguchi Hiroo

Research field (2)： Neuroscience - general , Neurology

Research keywords (2)：神経変性疾患 , 神経内科学

Research theme for competitive and other funds (18)：

2023 - 2026 ヘミチャネル阻害薬を用いたαシヌクレイン伝播阻止による多系統萎縮症の治療法開発
2023 - 2025 Elucidation of glia inflammation mechanisms common to degeneration and demyelination by novel pathogenic microglia
2022 - 2025 単一細胞RNA解析による多系統萎縮症増悪性ミクログリア亜群の同定と同細胞標的療法
2021 - 2024 多系統萎縮症モデルマウスを用いた画期的ミクログリア標的療法の開発
2020 - 2023 Novel therapy for progressive multiple sclerosis and multiple system atrophy by glial regulation

2019 - 2023 A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression

2019 - 2022 Misfold protein removal therapy with CCR2-positive cells from peripheral nerves in motor neuron disease

2019 - 2022 Establishment of primary-progressive multiple sclerosis (PPMS)/multiple system atrophy (MSA) mice model

2018 - 2021 A novel mice model of MSA by overexpression of mutant alpha-synuclein in oligodendroglia in a temporarily restrictive manner using Tet-off system

2017 - 2020 Impairment of insulin signaling in Alzheimer's disease and combined therapy with apomorphine and insulin

2017 - 2020 Elucidation of the role of glial cell in tau transmission and axonal degeneration in Alzheimer's disease and targeted therapy with glial cell

2016 - 2019 Elucidation of mechanisms for destruction and fixation of glia-syncytium in demyelinating diseases by whole-genome sequencing and immunohistochemical analysis.

2016 - 2019 Development of new therapeutic options for multiple sclerosis by suppression of CNS immune system augmentation due to the malfunction of astroglia connexin

2015 - 2018 New therapeutic investigation targetting to cell membrane protein induced by epileptic brain network

2015 - 2017 Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.

2014 - 2017 Analysis for mechanism of spontaneous seizures in a rat model of multiple prenatal freeze lesioning and development of novel treatment for epilepsy focusing on connexin

2014 - 2017 Extensive disruption of energy transports via glial syncytium in demyelinating diseases

2013 - 2015 To generate and analyze new Parkinson's disease mice model with increased oxidative stress

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Papers (32)：

Ezgi Ozdemir Takase, Ryo Yamasaki, Satoshi Nagata, Mitsuru Watanabe, Katsuhisa Masaki, Hiroo Yamaguchi, Jun-Ichi Kira, Hideyuki Takeuchi, Noriko Isobe. Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model. Scientific reports. 2024. 14. 1. 10877-10877
Satoshi Nagata, Ryo Yamasaki, Ezgi Ozdemir Takase, Kotaro Iida, Mitsuru Watanabe, Katsuhisa Masaki, Marion Heleen Cathérine Wijering, Hiroo Yamaguchi, Jun-Ichi Kira, Noriko Isobe. Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation. Biology. 2023. 12. 9
Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka, Eriko Matsuo, Shotaro Hayashida, Mitsuru Watanabe, Takuya Matsushita, Shoko Sadashima, et al. Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy. Brain pathology (Zurich, Switzerland). 2023. 33. 3. e13131
Ban-Yu Saitoh, Eizo Tanaka, Norio Yamamoto, Daan van Kruining, Kyoko Iinuma, Yuko Nakamuta, Hiroo Yamaguchi, Ryo Yamasaki, Koichiro Matsumoto, Jun-Ichi Kira. Early postnatal allergic airway inflammation induces dystrophic microglia leading to excitatory postsynaptic surplus and autism-like behavior. Brain, behavior, and immunity. 2021. 95. 362-380
Hayato Une, Ryo Yamasaki, Satoshi Nagata, Hiroo Yamaguchi, Yuko Nakamuta, Ulfa Camelia Indiasari, Yiwen Cui, Koji Shinoda, Katsuhisa Masaki, Magdalena Götz, et al. Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination. Journal of neuroinflammation. 2021. 18. 1. 126-126

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Professional career (1)：

医学博士(九州大学)

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