Terai Takuya

テライタクヤ | Terai Takuya

Affiliation and department：
Job title： Associate Professor

Research field (6)： Bioorganic chemistry , Chemical biology , Molecular biochemistry , Analytical chemistry , Pharmaceuticals - analytical and physicochemistry , Pharmaceuticals - chemistry and drug development

Research keywords (5)： chemical biology , bioimaging , fluorescent protein , fluorescent probe , evolutionary molecular engineering

Research theme for competitive and other funds (15)：

2024 - 2029 Development of near-infrared fluorescent biosensors through generative design and directed evolution
2024 - 2027 Massive Expansion of the Palette of Fluorescent Protein-based Sensors for Multiplexed Imaging of Signaling and Metabolism
2023 - 2026 Development of a series of chemigenetic fluorescence biosensors for multicolor and multiplexing bioimaging
2021 - 2023 Identification of ubiquitin ligase substrates and development of protein degradation method using evolutionary molecular engineering
2018 - 2021 Directed evolution of peptides that recognize dye structures and its application for research tools

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Papers (89)：

Fu Chai, Hajime Fujii, Giang N.T. Le, Chang Lin, Keisuke Ota, Karl Matthew Lin, Lam M.T. Pham, Peng Zou, Mikhail Drobizhev, Yusuke Nasu, et al. Development of an miRFP680-Based Fluorescent Calcium Ion Biosensor Using End-Optimized Transposons. ACS Sensors. 2024. 9. 6. 3394-3402
Saaya Hario, Giang N.T. Le, Hikaru Sugimoto, Kei Takahashi-Yamashiro, Suguru Nishinami, Hirofumi Toda, Selene Li, Jonathan S. Marvin, Shinya Kuroda, Mikhail Drobizhev, et al. High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular l-Lactate. ACS Central Science. 2024. 10. 2. 402-416
Wenchao Zhu, Shiori Takeuchi, Shosei Imai, Tohru Terada, Takumi Ueda, Yusuke Nasu, Takuya Terai, Robert E. Campbell. Chemigenetic indicators based on synthetic chelators and green fluorescent protein. Nature Chemical Biology. 2023. 19. 1. 38-44
Hiroki Anzai, Takuya Terai, Kanako Wakabayashi-Nakao, Taro Noguchi, Shigefumi Kumachi, Masayuki Tsuchiya, Naoto Nemoto. Interleukin-17A Peptide Aptamers with an Unexpected Binding Moiety Selected by cDNA Display under Heterogenous Conditions. ACS Medicinal Chemistry Letters. 2021. 12. 9. 1427-1434
Yasuhide Yamamoto, Takuya Terai, Shigefumi Kumachi, Naoto Nemoto. In Vitro Construction of Large-scale DNA Libraries from Fragments Containing Random Regions using Deoxyinosine-containing Oligonucleotides and Endonuclease V. ACS Combinatorial Science. 2020. 22. 4. 165-171

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MISC (11)：

Kelvin K. Tsao, Shosei Imai, Michael Chang, Saaya Hario, Takuya Terai, Robert E. Campbell. The best of both worlds: Chemigenetic fluorescent sensors for biological imaging. Cell chemical biology. 2024. 31. 9. 1652-1664
Saaya Hario, Shiori Takeuchi, Robert E. Campbell, Takuya Terai. Development of fluorescent imaging sensors based on proteins. Folia Pharmacologica Japonica. 2024. 159. 1. 25-30
Fu Chai, Dazhou Cheng, Yusuke Nasu, Takuya Terai, Robert E. Campbell. Maximizing the performance of protein-based fluorescent biosensors. Biochemical Society Transactions. 2023. 51. 4. 1585-1595
Takuya Terai, Robert E. Campbell. Barcodes, co-cultures, and deep learning take genetically encoded biosensor multiplexing to the nth degree. Molecular cell. 2022. 82. 2. 239-240
Aoi Takeda, Toru Komatsu, Hiroshi Nomura, Masamitsu Naka, Norio Matsuki, Yuji Ikegaya, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, et al. Cover Picture: Unexpected Photo-instability of 2,6-Sulfonamide-Substituted BODIPYs and Its Application to Caged GABA (ChemBioChem 13/2016). ChemBioChem. 2016. 17. 13. 1185

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Association Membership(s) (4)：

日本分子生物学会 , 日本ケミカルバイオロジー学会 , 日本薬学会 , 日本化学会

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