Wang Ziyi

ワンズーイー | Wang Ziyi

Affiliation and department：
Job title： Research Assistant Professor
Homepage URL (1)： https://linktr.ee/wongziyi

Research field (2)： Developmental dentistry , Regenerative dentistry and dental engineering

Research keywords (2)： Bone metabolism , Bioinformatics

Research theme for competitive and other funds (18)：

2024 - 2027 An international collaborative study to examine a novel hypothesis regarding the genetic background and mechanisms of anorexia nervosa caused by excessive exercise
2024 - 2027 Understanding the Mechanisms of Tooth Germ Development Using Spatial Single-Cell Epigenome Analysis
2024 - 2027 Constructing an in vivo High-Resolution Cell Lineage Analysis System Utilizing Cellular Barcoding Technology
2023 - 2027 Elucidation of early bone tissue construction through biological volume image analysis - from both cell and bone matrix perspectives -
2024 - 2026 GWAS・1細胞解析を応用した口蓋発達における力学的刺激伝達経路の解明

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Papers (37)：

Yao Weng, Ziyi Wang, Heriati Sitosari, Mitsuaki Ono, Hirohiko Okamura, Toshitaka Oohashi. O-GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum. BioFactors. 2024
Aung Ye Mun, Kentaro Akiyama, Ziyi Wang, Jiewen Zhang, Wakana Kitagawa, Teisaku Kohno, Ryuji Tagashira, Kei Ishibashi, Naoya Matsunaga, Tingling Zou, et al. Macrophages modulate mesenchymal stem cell function via tumor necrosis factor alpha in tooth extraction model. JBMR plus. 2024. 8. 8. ziae085
Anh Tuan Dang, Mitsuaki Ono, Ziyi Wang, Ikue Tosa, Emilio Satoshi Hara, Akihiro Mikai, Wakana Kitagawa, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi. Local E-rhBMP-2/β-TCP Application Rescues Osteocyte Dendritic Integrity and Reduces Microstructural Damage in Alveolar Bone Post-Extraction in MRONJ-like Mouse Model. International Journal of Molecular Sciences. 2024. 25. 12. 6648-6648
H.T. Do, M. Ono, Z. Wang, W. Kitagawa, A.T. Dang, T. Yonezawa, T. Kuboki, T. Oohashi, S. Kubota. Inverse genetics tracing the differentiation pathway of human chondrocytes. Osteoarthritis and Cartilage. 2024
Xindi Mu, Mitsuaki Ono, Ha Thi Thu Nguyen, Ziyi Wang, Kun Zhao, Taishi Komori, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi. Exploring the Regulators of Keratinization: Role of BMP-2 in Oral Mucosa. Cells. 2024. 13. 10. 807-807

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MISC (26)：

Xindi Mu, Mitsuaki Ono, Ha Nguyen, Ziyi Wang, Kun Zhao, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi. The Roles of BMP-2 on Modulating Oral Mucosal Keratinization. Journal of Dental Research. 2024. 103. Spec Iss A. 2089
Kun Zhao, Mitsuaki Ono, Xindi Mu, Ziyi Wang, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi. Enhancing Vertical Bone Regeneration With Fibrin-Infused E-RhBMP-2. Journal of Dental Research. 2024. 103. Spec Iss A. 0964
Ikue Tosa, Benjamin Kheyfets, Hyerin Yoon, Ziyi Wang, Mitsuaki Ono, Mildred Embree. Defining Cartilage Stem/Progenitor Cells During TMJ Development and Homeostasis. Journal of Dental Research. 2024. 103. Spec Iss A. 2726
Masaya Abe, Noboru Asada, Maiko Kimura, Chie Fukui, Daisuke Yamada, Ziyi Wang, Masayuki Miyake, Takeshi Takarada, Mitsuaki Ono, Michinori Aoe, et al. Alpha-Pinene As a Novel Therapeutic Agent for T-Cell Tumors. Blood. 2023. 142. Supplement 1. 1441-1441
Ziyi Wang, Satoru Hayano, Yao Weng, Xindi Mu, Mitsuaki Ono, Toshitaka Oohashi. A mechanosensor protein, Filamin A, mediated embryonic palate fusion through β-catenin/Smad2: A bioinformatics-oriented study. Journal of Bone and Mineral Research. 2023. 38. S2. S406-S407

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Lectures and oral presentations (10)：

Filamin A mediates embryonic palatal fusion by linking mechanotransduction with β-Catenin/Smad2
(7th Research Meeting for International Students 2024)
Filamin A mediated epithelial-mesenchymal transition during embryonic palate development
(The 46th Annual Meeting of Japanese Cleft Palate Association 2022)
The role of circadian rhythm and cell-to-cell communications in osteocytes mechanotransduction
(Bone-Bio-Engineering Kick-off Symposium 2020)
Changes of the spatial distribution of sclerostin may subject to the control of circadian rhythm in osteocytes during orthodontic tooth movement
(The 4th International Symposium of Medical and Dental Education in Okayama 2019)
Bioinformatics analysis shows candidate genes for osteocytes differentially response to different types of mechanical stimuli
(The 77th Annual Meeting of the Japanese Orthodontic Society 2018)

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Works (7)：

A ShinyApp for scRNA-seq analysis
Ziyi Wang 2024 -
Flow Cytometric Analysis Frame in R Programming Language
Ziyi Wang 2022 -
O-GlcNAcylation drives calcium signaling towards osteoblast differentiation: a bioinformatics-oriented study
Yao Weng, Ziyi Wang, Hiroshi Kamioka, Hirohiko Okamura 2021 -
Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes
Ziyi Wang, Yao Weng, Yoshihito Ishihara, Hiroshi Kamioka 2020 -
N-(3-oxododecanoyl)-homoserine lactone regulates intracellular calcium of MC3T3 osteoblasts
Jiajie Guo, Ziyi Wang, Lihong Qiu 2020 -

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Education (3)：

2016 - 2020 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Division of Science of Functional Recovery and Reconstruction
2014 - 2016 Dalian Medical University Graduate School of Dalian Medical University Dental School
2008 - 2013 Foshan University Dental School Dentistry

Professional career (1)：

Doctor of Philosophy in Dental Science (Okayama University)

Work history (7)：

2024/04 - 現在 Okayama University Molecular Biology and Biochemistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Research Assistant Professor
2022/04 - 2024/03 Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowships
2021/08 - 2022/03 Okayama University Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Technician
2021/04 - 2021/07 Okayama University Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Part-time Researcher
2019/04 - 2021/03 Japan Society for the Promotion of Science (JSPS) Research Fellowship

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Awards (5)：

2024/03 - Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University The Best Presentation of the 7th Research Meeting for International Students in Okayama University Filamin A mediates embryonic palatal fusion by linking mechanotransduction with β-Catenin/Smad2
2018/10 - The 77th Annual Meeting of the Japanese Orthodontic Society Best poster presentation Static force induces change of circadian clock genes in murine osteocytes might change sclerostin distribution
2018/10 - The 77th Annual Meeting of the Japanese Orthodontic Society Best oral presentation Bioinformatics analysis shows candidate genes for osteocytes differentially response to different types of mechanical stimuli
2018/08 - International Network of Advanced Dental Education & Research Excellent oral presentation of the14th Advanced Dental School Investigate the mechanotransduction of osteocytes: start with bioinformatics
2018/07 - The 36th Annual Meeting of the Japanese Society for Bone and Mineral Research Excellent poster presentation Mechanical signals influence circadian clock genes in murine osteocytes: implications for spatial distribution of sclerostin

Association Membership(s) (8)：

The American Society for Bone and Mineral Research (ASBMR) , Japanese Cleft Palate Association , Japanese Orthodontic Society , International Society of Bone Morphometry , Japanese Society for Bone and Mineral Research , Japanese Society For Bone Morphometry , Japanese Association for Oral Biology , Chinese Stomatological Association

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