Art
J-GLOBAL ID：202402227754571148   Reference number：24A0546043

Payload diversification: a key step in the development of antibody-drug conjugates

ペイロード多様化:抗体-薬物複合体の開発における重要な段階【JST・京大機械翻訳】
Author (6)：
Louise Conilh,

About Louise Conilh,

(Cancer Research Center of Lyon, UMR INSERM 1052; CNRS 5286, University of Lyon, Lyon, France)

About Cancer Research Center of Lyon, UMR INSERM 1052; CNRS 5286, University of Lyon, Lyon, France

, 
Louise Conilh,

About Louise Conilh,

(Mablink Bioscience, Lyon, France)

About Mablink Bioscience, Lyon, France

, 
Lenka Sadilkova,

About Lenka Sadilkova,

(Mablink Bioscience, Lyon, France)

About Mablink Bioscience, Lyon, France

, 
Warren Viricel,

About Warren Viricel,

(Mablink Bioscience, Lyon, France)

About Mablink Bioscience, Lyon, France

, 
Charles Dumontet,

About Charles Dumontet,

(Cancer Research Center of Lyon, UMR INSERM 1052; CNRS 5286, University of Lyon, Lyon, France)

About Cancer Research Center of Lyon, UMR INSERM 1052; CNRS 5286, University of Lyon, Lyon, France

, 
Charles Dumontet,

About Charles Dumontet,

(Hospices Civils de Lyon, Lyon, France)

About Hospices Civils de Lyon, Lyon, France


Material：
Journal of Hematology & Oncology (Web)

About Journal of Hematology & Oncology (Web)


Volume： 16  Issue： 1  Page： 1-28  Publication year： 2023 
JST Material Number： U7517A  ISSN： 1756-8722  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
All summary is available on JDreamIII(charged).
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Antibody-drug conjugates (ADCs...
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
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conjugation

About conjugation

,...
Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
トポイソメラーゼ

About トポイソメラーゼ

,...
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Author keywords (4)：
Antibody-drug conjugates

About Antibody-drug conjugates

, 
Payload

About Payload

, 
Topoisomerase 1 inhibitor

About Topoisomerase 1 inhibitor

, 
Cytotoxic molecule

About Cytotoxic molecule

JST classification (2)：
JST classification
Category name(code) classified by JST.
Basic research of antitumor(=antineoplastic)drugs 
(GW16010A)

About Basic research of antitumor(=antineoplastic)drugs

,  Drug therapy(=pharmacotherapy)for tumors 
(GE03032C)

About Drug therapy(=pharmacotherapy)for tumors

Reference (200)：
  • Nat Rev Cancer; Paul Ehrlich’s magic bullet concept: 100 years of progress; K Strebhardt, A Ullrich; 8; 2008; 473-480; 10.1038/nrc2394; citation_id=CR1
  • Nat Rev Drug Discov; Strategies and challenges for the next generation of antibody-drug conjugates; A Beck, L Goetsch, C Dumontet, N Corvaïa; 16; 2017; 315-337; 10.1038/nrd.2016.268; citation_id=CR2
  • Clin Cancer Res; Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia; PF Bross; 7; 2001; 1490-1496; citation_id=CR3
  • Blood; A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia; SH Petersdorf; 121; 2013; 4854-4860; 10.1182/blood-2013-01-466706; citation_id=CR4
  • Nat Rev Clin Oncol; Unlocking the potential of antibody-drug conjugates for cancer therapy; JZ Drago, S Modi, S Chandarlapaty; 18; 2021; 327-344; 10.1038/s41571-021-00470-8; citation_id=CR5
ｍore...
Terms in the title (5)：
Terms in the title
Keywords automatically extracted from the title.
ペイロード

About ペイロード

, 
多様化

About 多様化

, 
抗体-薬物複合体

About 抗体-薬物複合体

, 
開発

About 開発

, 
段階

About 段階


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