Art

J-GLOBAL ID：202402236532268172   Reference number：24A0109052

PLGA-Quercetin Nano-Formulation Inhibits Cancer Progression via Mitochondrial Dependent Caspase-3,7 and Independent FoxO1 Activation with Concomitant PI3K/AKT Suppression

PLGA-クエルセチンナノ形成はPI3K/AKT抑制を伴うミトコンドリア依存性カスパーゼ-3,7と独立FoxO1活性化を介して癌進行を阻害する【JST・京大機械翻訳】

Author (3)： Yadav Neera (College of Pharmacy, Gachon University, #191, Hambakmoeiro, Yeonsu-gu, Incheon 21936, Korea) ,  Tripathi Amit Kumar (Electrophysiology Lab, School of Biomedical Engineering, Banaras Hindu University, Varanasi 221005, India) ,  Parveen Amna (College of Pharmacy, Gachon University, #191, Hambakmoeiro, Yeonsu-gu, Incheon 21936, Korea)
Material： Pharmaceutics (Web)
Volume： 14  Issue： 7  Page： 1326  Publication year： 2022 
JST Material Number： U7258A  ISSN： 1999-4923  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Quercetin is one of the most i...

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Thesaurus term： hydrophobic ,  antitumor action ,  antitumor drug ,  human(primates) ,  *mitochondria ,  survival ratio ,  gene expression ,  adenocarcinoma ,  breast tumor ,  in vitro experiment ,  apoptosis ,  *poly(lactic-glycolic acid) ,  *caspase ,  nano particle ,  ketone ,  oxygen heterocyclic compound ,  polyphenol ,  flavonoid ,  polynuclear aromatic compound ,  hydroxy ketone

Author keywords (5)： quercetin ,  anti-cancer ,  phytochemical ,  drug delivery ,  FoxO1

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Quercetin

Reference (34)：

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• Kuang, W.; Hu, W.; Ren, H.; Shao, Y.; Liu, B. Plant derived coumestrol phytochemical targets human skin carcinoma cells by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and invasion and modulation of m-TOR/PI3K/AKT signalling pathway. Saudi J. Biol. Sci. 2021, 28, 2739-2746.
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Terms in the title (10)： PLGA ,  PI3K ,  Akt ,  ミトコンドリア ,  依存性 ,  カスパーゼ ,  FoxO1 ,  活性化 ,  癌進行 ,  阻害