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J-GLOBAL ID：202402238393735018   Reference number：24A0108002

Activation of SIRT-1 Pathway by Nanoceria Sheds Light on Its Ameliorative Effect on Doxorubicin-Induced Cognitive Impairment (Chemobrain): Restraining Its Neuroinflammation, Synaptic Dysplasticity and Apoptosis

ナノセリアによるSIRT-1経路の活性化はドキソルビシン誘発認知障害(Chemobrain)に対する改善作用に光を当てる:神経炎症,シナプス形成異常およびアポトーシスの抑制【JST・京大機械翻訳】

Author (10)： Taha Medhat (Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt) ,  Taha Medhat (Department of Anatomy, Al-Qunfudah Medical College, Umm Al-Qura University, Al-Qunfudhah 28814, Saudi Arabia) ,  Elazab Sara T. (Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt) ,  Badawy Alaa. M. (Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt) ,  Saati Abdullah A. (Department of Community Medicine and Pilgrims Healthcare, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia) ,  Qusty Naeem F. (Medical Laboratories Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 24382, Saudi Arabia) ,  Al-Kushi Abdullah G. (Department of Human Anatomy, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia) ,  Sarhan Anas (Department of Internal Medicine, College of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia) ,  Osman Amira (Department of Histology, Faculty of Medicine, Kafrelsheikh University, Kafr Elsheikh 33511, Egypt) ,  Farage Amira E. (Department of Anatomy and Embryology, Faculty of Medicine, Kafrelsheikh University, Kafr Elsheikh 33511, Egypt)
Material： Pharmaceuticals (Web)
Volume： 15  Issue： 8  Page： 918  Publication year： 2022 
JST Material Number： U7257A  ISSN： 1424-8247  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Chemo fog is one of the most s...

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Thesaurus term： gene ,  anti-inflammatory action ,  cytochrome c ,  rat ,  hippocampus ,  drug therapy ,  *agnosia ,  up-regulation ,  interleukin 6 ,  interleukin 1 ,  *apoptosis ,  oxidative stress ,  amino sugar ,  quinone ,  glycoside(except carbohydrate) ,  polyphenol ,  deoxysugar ,  pyranoside ,  phenol ether ,  polynuclear aromatic compound ,  hydroxy ketone ,  polyol
Semi thesaurus term： 神経変性 ,  *認知障害 ,  シナプス可塑性 , 【Automatic Indexing@JST】

Author keywords (5)： cerium oxide nanoparticles ,  doxorubicin ,  chemobrain ,  oxidative stress ,  synaptic plasticity

JST classification (5)： Basic research of cardioactive drugs  (GW07020N) ,  Basic research of other drugs acting on central nervous system  (GW03120U) ,  Cell physiology in general  (EF02010S) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (1)： Doxorubicin

Reference (102)：

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• Whittaker, A.L.; George, R.P.; O’Malley, L. Prevalence of cognitive impairment following chemotherapy treatment for breast cancer: A systematic review and meta-analysis. Sci. Rep. 2022, 12, 2135.

Terms in the title (10)： セリア ,  経路 ,  活性化 ,  ドキソルビシン ,  誘発 ,  認知障害 ,  改善作用 ,  神経炎症 ,  シナプス ,  アポトーシスの抑制