Art

J-GLOBAL ID：202402261612199577   Reference number：24A0349428

Therapeutic potential of a synthetic dual JAK1/TYK2 inhibitor in inflammatory bowel disease

炎症性腸疾患における合成二重JAK1/TYK2阻害剤の治療可能性【JST・京大機械翻訳】

Author (6)： Cui Xue (Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China) ,  Teng Yaxin (Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China) ,  Hu Yiguo (Department of Thyroid Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China) ,  Li Qingqing (Innovation Center of Nursing Research and Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, China) ,  Pei Heying (Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China) ,  Yang Zhuang (Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China)
Material： International Immunopharmacology  (Int Immunopharmacol)
Volume： 126  Page： Null  Publication year： 2024 
JST Material Number： T0026B  ISSN： 1567-5769  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Inflammatory bowel disease (IB...

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Thesaurus term： interferon ,  *Inflammation ,  Mortality ,  side effect ,  *Mus musculus ,  phosphorylation ,  small molecule ,  long term administration ,  in vitro experiment ,  pathogenesis ,  STAT transcription factor ,  *Inflammatory Bowel Diseases ,  *Janus Kinase 1 ,  signal transduction pathway ,  mouse model ,  *Myomorpha ,  molecular targeting drug

Author keywords (4)： JAK1 ,  TYK2 ,  Dual inhibitor ,  Inflammatory bowel disease

JST classification (1)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Tofacitinib

Terms in the title (6)： 炎症性腸疾患 ,  JAK1 ,  Tyk2 ,  阻害剤 ,  治療 ,  可能性