Art

J-GLOBAL ID：202402261715485250   Reference number：24A0136649

Development of a Physiologically Based Pharmacokinetic Model for Tegoprazan: Application for the Prediction of DrugDrug Interactions with CYP3A4 Perpetrators

テゴプラザンの生理学的薬物動態モデルの開発:CYP3A4パーペトレーターとの薬物相互作用の予測への応用【JST・京大機械翻訳】

Author (4)： Ngo Lien Thi ,  Lee Jaeyeon ,  Yun Hwi-yeol ,  Chae Jung-woo
Material： Pharmaceutics (Web)
Volume： 15  Issue： 1  Page： 182  Publication year： 2023 
JST Material Number： U7258A  ISSN： 1999-4923  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Tegoprazan is a novel potassiu...

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Thesaurus term： electric potential ,  inducer ,  metabolite ,  *drug interaction ,  *pharmacokinetics ,  cytochrome P450 ,  health care ,  case study ,  gastroesophageal reflux ,  area under the blood concentration time curve ,  amino sugar ,  ether ,  macrocyclic compound ,  lactone ,  glycoside(except carbohydrate) ,  deoxysugar ,  pyranoside ,  sugar ether ,  diol ,  tertiary amine ,  hydroxy ketone ,  fatty acid ,  hydrazone ,  lactam ,  oxygen heterocyclic compound ,  polyphenol ,  bridged compound ,  polynuclear aromatic compound ,  carboxylate(ester) ,  polyol
Semi thesaurus term： 最高血中濃度 ,  治療適応 ,  Helicobacter pylori感染症 , 【Automatic Indexing@JST】

Author keywords (5)： tegoprazan ,  PBPK model ,  drug-drug interaction ,  CYP3A4 ,  metabolism

JST classification (1)： Interactions of drugs  (GV01070X)

Substance index (2)： Clarithromycin ,  Rifampin

Reference (26)：

• He, J.; Cao, G.; Yu, J.; Wang, J.; Cheng, N.; Wu, J.; Zhang, J.; Wu, X.; Zhang, B.; Lu, J.; et al. Safety, Tolerability and Pharmacokinetics of Single Ascending and Multiple Oral Doses of Tegoprazan in Healthy Chinese Subjects. Clin. Drug. Investig. 2021, 41, 89-97.
• K-CAB Tab. 50 mg. Available online: https://www.health.kr/searchDrug/result_drug.asp?drug_cd=2018070600004 (accessed on 15 February 2022). Tegoprazan (K-CAB). Available online: http://www.endotoday.com/endotoday02/temp.pdf (accessed on 18 March 2022).
• Jeong, H.-C.; Kim, M.-G.; Wei, Z.; Lee, K.-R.; Lee, J.; Song, I.-S.; Shin, K.-H. Integration of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Tegoprazan and Its Metabolite: Application for Predicting Food Effect and Intragastric pH Alterations. Pharmaceutics 2022, 14, 1298.
• Yoon, D.Y.; Lee, S.; Jang, I.-J.; Kim, M.; Lee, H.; Kim, S.; Kim, B.; Song, G.S.; Rhee, S. Prediction of Drug-Drug Interaction Potential of Tegoprazan Using Physiologically Based Pharmacokinetic Modeling and Simulation. Pharmaceutics 2021, 13, 1489.
• Ghim, J.; Chin, M.C.; Jung, J.; Lee, J.; Kim, S.; Kim, B.; Song, G.S.; Choi, Y.; Shin, J. Pharmacokinetics and Pharmacodynamics of Tegoprazan Coadministered with Amoxicillin and Clarithromycin in Healthy Subjects. J. Clin. Pharmacol. 2021, 61, 913-922.

Terms in the title (6)： 生理学的薬物動態モデル ,  開発 ,  CYP3A4 ,  薬物相互作用 ,  予測 ,  応用