Art

J-GLOBAL ID：202402267291861776   Reference number：24A0290861

Lymphodepletion - an essential but undervalued part of the chimeric antigen receptor T-cell therapy cycle

リンパ球枯渇-キメラ抗原受容体T細胞治療サイクルの必須だが,値下部分【JST・京大機械翻訳】

Author (20)： Lickefett Benno (1Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria) ,  Chu Lulu (2Cell Therapy Clinical Pharmacology and Modeling, Takeda, Boston, MA, United States) ,  Ortiz-Maldonado Valentin (3Department of Hematology, Hospital Clinic de Barcelona, Barcelona, Spain) ,  Warmuth Linda (4Institut fuer Med. Mikrobiologie, Immunologie und Hygiene, Technische Universitaet Munich, Munich, Germany) ,  Barba Pere (5Hematology Department, Hospital Universitari Vall d’Hebron, Barcelona, Spain) ,  Doglio Matteo (6Experimental Hematology Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy) ,  Henderson David (7Bayer Aktiengesellschaft (AG), Business Development & Licensing & Open Innovation (OI), Pharmaceuticals, Berlin, Germany) ,  Hudecek Michael (8Lehrstuhl fuer Zellulaere Immuntherapie, Medizinische Klinik und Poliklinik II, Universitaetsklinikum Wuerzburg, Wuerzburg, Germany) ,  Kremer Andreas (9ITTM S.A. (Information Technology for Translational Medicine), Esch-sur-Alzette, Luxembourg) ,  Markman Janet (2Cell Therapy Clinical Pharmacology and Modeling, Takeda, Boston, MA, United States) ,  Nauerth Magdalena (4Institut fuer Med. Mikrobiologie, Immunologie und Hygiene, Technische Universitaet Munich, Munich, Germany) ,  Negre Helene (10Institut de Recherches Internationales Servier, Suresnes, France) ,  Sanges Carmen (8Lehrstuhl fuer Zellulaere Immuntherapie, Medizinische Klinik und Poliklinik II, Universitaetsklinikum Wuerzburg, Wuerzburg, Germany) ,  Staber Philipp B. (1Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria) ,  Tanzi Rebecca (10Institut de Recherches Internationales Servier, Suresnes, France) ,  Delgado Julio (3Department of Hematology, Hospital Clinic de Barcelona, Barcelona, Spain) ,  Busch Dirk H. (4Institut fuer Med. Mikrobiologie, Immunologie und Hygiene, Technische Universitaet Munich, Munich, Germany) ,  Kuball Juergen (11Legal and Regulatory Affairs Committee of the European Society for Blood and Marrow Transplantation, Leiden, Netherlands) ,  Luu Maik (8Lehrstuhl fuer Zellulaere Immuntherapie, Medizinische Klinik und Poliklinik II, Universitaetsklinikum Wuerzburg, Wuerzburg, Germany) ,  Jaeger Ulrich (1Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria)
Material： Frontiers in Immunology (Web)
Volume： 14  Page： 1303935  Publication year： 2023 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Lymphodepletion (LD) or condit...

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Thesaurus term： optimization ,  safety ,  side effect ,  *lymph ,  *lymphocyte ,  bender ,  *T cell ,  *antigen receptor ,  B cell lymphoma ,  aliphatic alcohol ,  sulfonate ,  diol
Semi thesaurus term： T細胞サブセット ,  CD19抗原 ,  移植片生着 ,  内因性 ,  コンソーシアム ,  *キメラ抗原受容体 , 【Automatic Indexing@JST】

Author keywords (6)： CAR-T cells ,  lymphodepletion ,  conditioning ,  optimization ,  efficacy ,  toxicity

JST classification (2)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Immunotherapy for tumors  (GE03035B)

Substance index (1)： Busulfan

Reference (163)：

• Rosenberg SA, Spiess P, Lafreniere R. A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science (1986) 233(4770):1318-21. doi: doi: 10.1126/science.3489291
• Gross G, Waks T, Eshhar Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci U.S.A. (1989) 86(24):10024-8. doi: doi: 10.1073/pnas.86.24.10024
• Eshhar Z, Gross G. Chimeric T cell receptor which incorporates the anti-tumour specificity of a monoclonal antibody with the cytolytic activity of T cells: a model system for immunotherapeutical approach. Br J Cancer Suppl (1990) 10:27-9. doi: 10.1073/pnas.86.24.10024
• Gardner RA, Finney O, Annesley C, Brakke H, Summers C, Leger K, et al. Intent-to-treat leukemia remission by CD19 CAR T cells of defined formulation and dose in children and young adults. Blood (2017) 129(25):3322-31. doi: doi: 10.1182/blood-2017-02-769208
• Park JH, Riviere I, Gonen M, Wang X, Senechal B, Curran KJ, et al. Long-term follow-up of CD19 CAR therapy in acute lymphoblastic leukemia. N Engl J Med (2018) 378(5):449-59. doi: doi: 10.1056/NEJMoa1709919

Terms in the title (5)： リンパ球枯渇 ,  キメラ抗原受容体 ,  T細胞 ,  治療 ,  サイクル