Art

J-GLOBAL ID：202402271700891364   Reference number：24A0142829

Polyethyleneglycol-Betulinic Acid (PEG-BA) Polymer-Drug Conjugate Induces Apoptosis and Antioxidation in a Biological Model of Pancreatic Cancer

ポリエチレングリコール-ベツリン酸(PEG-BA)高分子-薬物複合体は膵臓癌の生物学的モデルにおけるアポトーシスと抗酸化を誘導する【JST・京大機械翻訳】

Author (4)： Mosiane Karabo Sekopi (Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa) ,  Nweke Ekene Emmanuel (Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa) ,  Balogun Mohammed (Biopolymer Modification and Therapeutics Lab, Materials Science & Manufacturing, Council for Scientific and Industrial Research, Meiring Naude Road, Brummeria, Pretoria 0001, South Africa) ,  Fru Pascaline Nanga (Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa)
Material： Polymers (Web)
Volume： 15  Issue： 2  Page： 448  Publication year： 2023 
JST Material Number： U7262A  ISSN： 2073-4360  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Pancreatic cancer (PC) is one ...

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Thesaurus term： conjugation ,  gene ,  anti-inflammatory action ,  antitumor action ,  *tumor ,  *complex(substance) ,  cell cycle ,  conjugation(metabolism) ,  survival ratio ,  gene expression ,  *pancreatic tumor ,  *apoptosis ,  herb
Semi thesaurus term： 悪性腫瘍 ,  p65 ,  抗酸化活性 ,  過剰発現 , 【Automatic Indexing@JST】

Author keywords (5)： Polyethyleneglycol-betulinic acid ,  conjugation ,  apoptosis ,  antioxidation ,  reactive oxygen species

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Reference (83)：

• Siegel, R.L.; Miller, K.D.; Fuchs, H.E.; Jemal, A. Cancer statistics, 2021. CA Cancer J. Clin. 2021, 71, 7-33.
• Maisonneuve, P. Epidemiology and burden of pancreatic cancer. Presse Médicale 2019, 48, e113-e123.
• Kleeff, J.; Korc, M.; Apte, M.; La Vecchia, C.; Johnson, C.D.; Biankin, A.V.; Neale, R.E.; Tempero, M.; Tuveson, D.A.; Hruban, R.H.; et al. Pancreatic cancer. Nat. Rev. Dis. Primer. 2016, 2, 16022.
• Kim, A.; Ha, J.; Kim, J.; Cho, Y.; Ahn, J.; Cheon, C.; Kim, S.; Ko, S.; Kim, B. Natural products for pancreatic cancer treatment: From traditional medicine to modern drug discovery. Nutrients. 2021, 13, 3801.
• Yogeeswari, P.; Sriram, D. Betulinic acid and its derivatives: A review on their biological properties. Curr. Med. Chem. 2005, 12, 657-666.

Terms in the title (12)： ポリエチレングリコール ,  ベツリン酸 ,  PEG ,  Ba ,  高分子 ,  薬物 ,  複合体 ,  膵臓癌 ,  生物学的モデル ,  アポトーシス ,  酸化 ,  誘導