Art

J-GLOBAL ID：202402287894336369   Reference number：24A0587050

Gasdermins: a dual role in pyroptosis and tumor immunity

ガスデルミン:ピロトーシスと腫瘍免疫における二重の役割【JST・京大機械翻訳】

Author (6)： Yang Jiayi (Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China) ,  Yang Jiayi (Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China) ,  Yang Jiayi (Institute of Cell Therapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China) ,  Jiang Jingting (Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China) ,  Jiang Jingting (Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China) ,  Jiang Jingting (Institute of Cell Therapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China)
Material： Frontiers in Immunology (Web)
Volume： 15  Page： 1322468  Publication year： 2024 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The gasdermin (GSDM) protein f...

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Thesaurus term： inflammation ,  *tumor ,  protein ,  *immunity ,  bacterial infection(phenomenon) ,  immunotherapy ,  tumor invasion ,  protein complex ,  *apoptosis ,  pathogenesis ,  *tumor immunity ,  caspase
Semi thesaurus term： エフェクター細胞 ,  インフラマソーム ,  シグナル伝達経路 ,  炎症性疾患 ,  *ピロトーシス , 【Automatic Indexing@JST】

Author keywords (6)： gasdermin ,  pyroptosis ,  caspase ,  granzyme ,  tumor immunity ,  immunotherapy

JST classification (2)： Cell physiology in general  (EF02010S) ,  Immunological reaction in general  (ED03010T)

Reference (131)：

• Johnson AG, Wein T, Mayer ML, Duncan-Lowey B, Yirmiya E, Oppenheimer-Shaanan Y, et al. Bacterial gasdermins reveal an ancient mechanism of cell death. Science (2022) 375(6577):221-5. doi: doi: 10.1126/science.abj8432
• Liu Z, Busscher BM, Storl-Desmond M, Xiao TS. Mechanisms of gasdermin recognition by proteases. J Mol Biol (2022) 434(4):167274. doi: doi: 10.1016/j.jmb.2021.167274
• Broz P, Pelegrín P, Shao F. The gasdermins, a protein family executing cell death and inflammation. Nat Rev Immunol (2020) 20(3):143-57. doi: doi: 10.1038/s41577-019-0228-2
• Ding J, Wang K, Liu W, She Y, Sun Q, Shi J, et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature (2016) 535(7610):111-6. doi: doi: 10.1038/nature18590
• de Vasconcelos NM, Lamkanfi M. Recent insights on inflammasomes, gasdermin pores, and pyroptosis. Cold Spring Harb Perspect Biol (2020) 12(5):a036392. doi: doi: 10.1101/cshperspect.a036392

Terms in the title (3)： ピロトーシス ,  腫瘍免疫 ,  役割