Art

J-GLOBAL ID：202402289637017483   Reference number：24A0074179

Acetaminophen-Its mechanism of action and analgesic effect-

アセトアミノフェン-その作用機序と鎮痛効果-

Author (2)： YAMAMOTO TATSUO (船橋整形外科病院 麻酔科) ,  YAMAMOTO TATSUO (埼玉医大 病院 麻酔科)
Material： ペインクリニック  (Pain Clinic)
Volume： 44  Issue： 7  Page： 660-665  Publication year： Aug. 25, 2023 
JST Material Number： G0739B  ISSN： 0388-4171  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human(primates) ,...
Semi thesaurus term： therapeutic indication

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JST classification (2)： Clinical application of psychotropic drugs  (GW03110J) ,  Clinical biopharmacy  (GY01022L)

Substance index (1)： Acetaminophen

Reference (19)：

• Ohashi N, Kohno T : Analgesic effect of acetaminophen : a review of known and novel mechanisms of action. Front Pharmacol 2020 ; 11 : 580289
• Chandrasekharan NV, Dai H, Roos KL, et al : COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs : cloning, structure, and expression. Proc Natl Acad Sci USA 2002 ; 99 : 13926-31
• Högestätt ED, Jönsson BAG, Ermund A, et al : Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem 2005 ; 280 : 31405-12
• Ohashi N, Uta D, Sasaki M, et al : Acetaminophen metabolite N-acylphenolamine induces analgesia via transient receptor potential vanilloid 1 receptors expressed on the primary afferent terminals of C-fibers in the spinal dorsal horn. Anesthesiology 2017 ; 127 : 355-71
• Nakamura S, Nonaka T, Komatsu S, et al : Oral acetaminophen-induced spinal 5-hydroxytriyptamine release produces analgesic effects in the rat formalin test. Biomed Pharmacother 2022 ; 146 : 112578

Terms in the title (3)： アセトアミノフェン ,  作用機序 ,  鎮痛効果