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J-GLOBAL ID：200902249765083796   Reference number：09A0461870

Quantitative Comparison of the Convulsive activity of Combinations of Twelve Fluoroquinolones with Five Nonsteroidal Antiinflammatory Agents

12種のフルオロキノロン剤と5種の非ステロイド性抗炎症剤との組み合わせにおける痙攣作用の定量的比較

Author (5)： KIM Jahye (Dep. of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu Univ.) ,  OHTANI Hisakazu (Lab. of Drug Informatics, Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo) ,  TSUJIMOTO Masayuki (Dep. of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu Univ.) ,  SAWADA Yasufumi (Lab. of Drug Informatics, Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo) ,  SAWADA Yasufumi (Graduate School of Interdisciplinary Information Studies, The Univ. of Tokyo)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 24  Issue： 2  Page： 167-174 (J-STAGE)  Publication year： 2009 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： quinolone anti-bacterial agent ,...
Semi thesaurus term： *non-steroidal anti-inflammatory agent ,...

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JST classification (2)： Nervous system diseases  (GN03000O) ,  Interactions of drugs  (GV01070X)

Substance index (18)： Ciprofloxacin ,  Enoxacin ,  Fleroxacin ,  Gatifloxacin ,  Levofloxacin ,  Lomefloxacin ,  Norfloxacin ,  Ofloxacin ,  Pazufloxacin ,  Prulifloxacin ,  Sparfloxacin ,  Tosufloxacin ,  Felbinac ,  Diclophenac sodium ,  Zaltoprofen ,  Loxoprofen ,  Lornoxicam ,  Diclofenac

Reference (41)：

• 1) Owens, R. C. Jr and Ambrose, P. G.: Antimicrobial safety: focus on fluoroquinolones. Clin. Infect. Dis., 41 Suppl 2: S144-S157 (2005).
• 2) Lipsky, B. A. and Baker, C. A.: Fluoroquinolone toxicity profiles: a review focusing on newer agents. Clin. Infect. Dis., 28: 352-364 (1999).
• 3) Akahane, K., Sekiguchi, M., Une, T. and Osada, Y.: Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites. Antimicrob. Agents Chemother., 33: 1704-1708 (1989).
• 4) Squires, R. F. and Saederup, E.: Indomethacin/ibuprofen-like anti-inflammatory agents selectively potentiate the gamma-aminobutyric acid-antagonistic effects of several norfloxacin-like quinolone antibacterial agents on. Mol. Pharmacol., 43: 795-800 (1993).
• 5) Shirasaki, T., Harata, N., Nakaye, T. and Akaike, N.: Interaction of various non-steroidal anti-inflammatories and quinolone antimicrobials on GABA response in rat dissociated hippocampal pyramidal neurons. Brain Res., 562: 329-331 (1991).

Terms in the title (5)： フルオロキノロン剤 ,  非ステロイド性抗炎症剤 ,  組み合わせ ,  痙攣作用 ,  定量