Art

J-GLOBAL ID：201402263807381418   Reference number：14A0032376

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

代謝:Acc1およびAcc2に存在する単一のリン酸化部位は脂質恒常性とメトホルミンのインスリン感作効果を調節する

Author (22)： FULLERTON Morgan D (McMaster Univ., Ontario, CAN) ,  MARCINKO Katarina (McMaster Univ., Ontario, CAN) ,  SIKKEMA Sarah (McMaster Univ., Ontario, CAN) ,  O'NEILL Hayley M (McMaster Univ., Ontario, CAN) ,  FORD Rebecca J (McMaster Univ., Ontario, CAN) ,  PALANIVEL Rengasamy (McMaster Univ., Ontario, CAN) ,  SCHERTZER Jonathan D (McMaster Univ., Ontario, CAN) ,  STEINBERG Gregory R (McMaster Univ., Ontario, CAN) ,  GALIC Sandra (St. Vincent’s Inst. of Medical Res., Victoria, AUS) ,  CHEN Zhi-Ping (St. Vincent’s Inst. of Medical Res., Victoria, AUS) ,  O'NEILL Hayley M (St. Vincent’s Inst. of Medical Res., Victoria, AUS) ,  O'BRIEN Matthew (St. Vincent’s Inst. of Medical Res., Victoria, AUS) ,  VAN DENDEREN Bryce J (St. Vincent’s Inst. of Medical Res., Victoria, AUS) ,  KEMP Bruce E (St. Vincent’s Inst. of Medical Res., Victoria, AUS) ,  STEINBERG Gregory R (St. Vincent’s Inst. of Medical Res., Victoria, AUS) ,  PULINILKUNNIL Thomas (Univ. Alberta, Alberta, CAN) ,  DYCK Jason R B (Univ. Alberta, Alberta, CAN) ,  O'NEILL Hayley M (Univ. Melbourne, Victoria, AUS) ,  O'BRIEN Matthew (Univ. Melbourne, Victoria, AUS) ,  KEMP Bruce E (Univ. Melbourne, Victoria, AUS) ,  HARDIE D Grahame (Univ. Dundee, Dundee, GBR) ,  MACAULAY S Lance (Commonwealth Scientific and Industrial Res. Organisation Preventative Health Flagship, Materials Sci. and Engineering,...)
Material： Nature Medicine  (Nat Med)
Volume： 19  Issue： 12  Page： 1649-1654  Publication year： Dec. 2013 
JST Material Number： W0636A  ISSN： 1078-8956  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *phosphorylation ,  *amino acid residue ,  homeostasis ,  lipid ,  hypoglycemic drug ,  sensitization(immunology) ,  *fatty liver ,  serine-threonine kinase ,  *acetyl-CoA carboxylase ,  vitamin B family ,  metabolite ,  *lipid metabolism ,  mitochondria ,  *biological transport ,  allosteric effect ,  mouse(animal) ,  laboratory animal ,  metabolic disease ,  obesity ,  acyl CoA ,  aliphatic amine ,  insulin ,  *type 2 diabetes mellitus ,  *insulin resistance
Semi thesaurus term： insulin ,  *non-insulin-dependent diabetes mellitus ,  *insulin resistance ,  AMPK ,  allosteric inhibition ,  energy homeostasis ,  knock-in mouse ,  *phosphorylation site ,  *lipid transfer ,  *fatty acid biosynthesis ,  Sugar intolerance ,  *Non alcoholic fatty liver disease

JST classification (3)： Metabolism in general  (EB05030X) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Enzyme in general  (EB09010D)

Substance index (3)： Acetyl Coenzyme A ,  Malonyl CoA ,  Metformin

Terms in the title (8)： 代謝 ,  リン酸化部位 ,  脂質 ,  恒常性 ,  メトホルミン ,  インスリン ,  感作 ,  調節